骨髓间充质干细胞与子宫内膜再生

Bone Marrow Mesenchymal Stem Cells and Endometrial Regeneration

体外受精-胚胎移植的成功受很多因素的影响,其中过薄的子宫内膜会降低子宫内膜容受性,导致胚胎着床失败,结局不良。目前治疗薄型子宫内膜的手段多集中于增加雌激素水平、改善子宫内膜血流以及子宫内膜微创刺激等方面,但疗效并不理想。骨髓间充质干细胞具有自我更新和多向分化的潜能,是最好的成体间充质干细胞来源,可用于治疗多种损伤性疾病。近期研究表明其可向子宫内膜迁移,使子宫内膜厚度增加,并改善子宫内膜容受性,为治疗薄型子宫内膜提供新的思路。

The success of in vitro fertilization-embryo transplantation （IVF-ET） is affected by many factors. Thin endometrium can reduce the receptivity of endometrium,which results in the failure of the embryo implantation. Currently,the common treatment for thin endometrium is focused on increasing estrogen,improving the endometrial blood flow and the endometrial minimally invasive stimulation. However ,the above methods are not enough effective. Bone marrow mesenchymal stem cells （BMSCs） with the characteristics of self-renewal and multipotential differentiation are the best source of mesenchymal stem cells ,which can be used to treat many injury diseases. Recent studies have shown that BMSCs can migrate to endometrium , increase endometrial thickness,and improve the receptivity of endometrium. BMSCs may be a prospective method for the treatment of thin endometrium.