转化生长因子-β1/Smads信号在增生性瘢痕形成中的作用研究进展

Review on the role of TGF-β1/Smads signaling in the formation of hypertrophic scar

病理性的创面愈合常导致增生性瘢痕的形成,并伴随疼痛、瘙痒和挛缩,给患者带来生理和心理上的巨大痛苦。肌成纤维细胞的过度增殖及细胞外基质的过度沉积是增生性瘢痕的重要特征,其中TGF(转化生长因子)-β1/Smads信号的调节发挥了重要作用。抑制TGF-β1/Smads可抑制细胞的过度增殖,减少细胞外基质的沉积。目前针对该信号通路抗增生性瘢痕形成的研究日益增多,为减少瘢痕的形成及减轻瘢痕提供了重要的依据。本文就肌成纤维细胞及细胞外基质在增生性瘢痕中的作用及TGF-β1/Smads在增生性瘢痕形成调节中发挥的重要作用作一综述。

Hypertrophic scars（ HS） form as a result of pathological wound healing.By causing pain,pruri-tus and contractures,HS significantly affects the patients’ quality of life,both physically and psychologically.Over-proliferation of myofibroblasts and excessive deposition of extracellular matrix are characteristics of the HS,which are dominantly regulated by transforming growth factor-β1/drosophila mothers against decapentaplegic proteins （ TGF-β1/Smads） signaling.By inhibiting the signaling of TGF-β1/Smads,HS can be alleviated.Multiple researches fo-cus on preventing or attenuating HS against the signaling,providing important basis for therapies of HS.In this pa-per we summarize the roles of myofibroblasts and extracellular matrix in the process of HS, and the regulation of TGF-β1/Smads signaling during HS formation.