大戟甘草反药组合宜忌条件的实验研究回顾与评析

Review on the experimental studies of suitable and contraindicant conditions of Chinese medicine antagonism compatibility euphorbia pekinensis and glycyrrhiza

利用中国知网、万方、维普、Pub Med数据库,系统检索1949年以来关于"十八反"中大戟甘草反药组合同用的研究文献,检索文章的过程中剔除综述及临床研究类文章,选取实验研究方面的文章,总结归纳大戟甘草反药组合配伍使用的宜忌条件。结果显示对大戟与甘草配伍宜忌条件的研究多集中在配伍剂量、配伍比例、煎煮方式、给药途径、大戟品种等方面。在给药剂量方面,按照临床规定安全剂量给药时大部分表现为"不反";而两药的倍量使用,则表现出一定的相反趋势。给药途径方面,腹腔注射是禁忌条件。而其他几方面未区分出明确的"反"与"不反"的条件。笔者认为大戟甘草能否同用不能一概而论,而是受到不同条件的限制,单一条件下得出的结果只能作为参考,而不能成为定论。且发现实验研究多在生理条件下对单纯反药组合进行探讨,希望今后病理状态下含反药组合的复方研究能引起人们的重视,使"十八反"的研究更具临床指导意义。

This article summarized the suitable conditions and contraindicant conditions of antagonism compatibility euphorbia pekinensis and glycyrrhiza from the selected experimental research articles by searching“euphorbia pekinensis and glycyrrhiza compatibility of Chinese medicine Eighteen an-tagonism” from Wan Fang, CNKI, and VIP database since 1949. The studies of suitable and contraindicant conditions of euphorbia pekinensis and glycyrrhiza focused on proportion, dose, method of decoction,route of administration, varieties of euphorbia pekinensis, and so on. The result is that the dose around to the clinical dose is the suitable conditions, while the contraindicant condition is as twice as the clinical dose. On the route of administration, injecting is contraindicant condition. While other conditions can’ t be classified clearly into suitable and contraindicant ones. In my opinion, whether euphorbia pekinensis and glycyrrhiza can be used together or not is limited by different conditions but can ’ t be generalized in a few words. The results obtained under a single condition can only be as a reference, but not be conclusive. What ’ s more, we find that, the experiment researches are usually took under physiological conditions and the object is purely antagonism compatibility itself. We hope more researches will be done under pathological conditions so that providing important evidences for the clinician.