健脾祛痰化瘀法防治动脉粥样硬化的临床研究进展

Advances in the clinical researches of treating atherosclerosis via the method of invigorating spleen,removing phlegm and eliminating blood statisis

对健脾祛痰化瘀法防治动脉粥样硬化的研究进行了文献整理和分析,以健脾、祛痰、化瘀、动脉粥样硬化等为主题词进行了文献检索。从血脂、免疫炎症、抗氧化和血管张力调节这4方面总结了中药防治动脉粥样硬化的研究进展。并且从上述4方面内容,对近10年来的动物实验和临床随机对照实验进行了分析归纳。健脾祛痰化瘀类方剂对动脉粥样硬化患者的血脂紊乱状态有显著地纠正作用,并且也有抗炎、抗氧化应激与舒张血管作用。进一步探讨了此类方剂防治动脉粥样硬化的优势,以及开发此类方剂对于中医药防治动脉粥样硬化的广阔前景。

In this review, current researches on the TCM drug therapies of atherosclerosis via the method of invigorating spleen, removing phlegm and eliminating stagnated blood were summarized and an-alyzed. These methods and atherosclerosis were used as key words for literature search. We analyze animal experiments and RCT studies of the recent 10 years in 4 aspects：inflammations,dyslipidemia,an-tioxidation as well as angiotasis regulation. It turns out that： this kind of therapy plays a very important role in correcting dyslipidemia,anti-inflammtion as well as antioxidation and vasodilatation. However,our scholars concentrate more on its correction of dyslipidemia. We also further discuss the advantages of this therapy and its spectacular prospects for treating and protecting atherosclerosis.