综述细胞外信号调节激酶1/2信号通路与肝肾亏虚型膝骨关节炎的相关性

Review on correlation between ERK1/2 signaling pathway and knee osteoarthritis with syndrome of deficiency of liver and kidney

细胞外信号调节激酶(ERK)是丝裂原活化蛋白激酶家族中的一个重要亚型,细胞外信号调节通路在膝骨关节炎发病过程中持续表达,对软骨细胞的增殖、凋亡有重要调节作用。肝肾亏虚为膝骨关节炎的常见证型,而补肝肾中药能有效调控细胞外信号调节激酶1/2(ERK1/2)的表达以达到治疗膝骨关节炎的效果。研究ERK1/2与肝肾亏虚型膝骨关节炎的关系,能为揭示该病的发病机制和指导其临床治疗提供新依据和思路。

Extracellular signal-regulated kinase （ERK） is an important subtype of mitogen-activated protein kinase （MAPK） family. Continuous expression of ERK pathway in the pathogenesis of knee osteoarthritis （KOA） plays an important role in regulating proliferation and apoptosis of chondrocytes. The common syndromeof KOA is syndrome of deficiency of liver and kidney, and drugs ofnourishing liver and kidneycan treat KOA through regulate the expression of ERK1/2 effectively. Studying the correlation between ERK1/2 signaling pathway and knee osteoarthritis with syndrome of deficiency of liver and kidneycan provides new evidences and ideas for revealing pathogenesis and guiding clinical treatment of this disease.