microRNA-146a与寻常型银屑病(血热型)严重性指数的相关性研究及竹黄颗粒的临床干预作用

Study on the relation between microRNA-146a and PASI index of psoriasis vulgaris(blood heat syndrome) and the effect of clinical intervention by Zhuhuang Particle

目的:研究micro RNA-146a与寻常型银屑病(血热型)皮损面积和严重性指数(PASI)指数的相关性以及竹黄颗粒的临床干预作用。方法:以64例寻常型银屑病(血热型)的患者为研究对象,检测其外周血中mi RNA-146a的表达水平,对治疗前患者外周血中mi RNA-146a的表达水平与其PASI指数作直线相关分析。再将这些患者随机分成两组,各32例。治疗组予以竹黄颗粒口服、对照组口服复方青黛丸,4周为1个疗程,共2个疗程。并观察两组治疗前后PASI指数的下降程度,以此来反映竹黄颗粒的临床疗效。结果:外周血mi RNA-146a的表达和PASI指数经过直线相关性分析有正相关关系(r=0.92,P<0.05),治疗后,竹黄颗粒治疗组较对照组PASI指数下降明显(P<0.01)。结论:micro RNA-146a与PASI指数呈正相关,说明血清中mi RNA-146a的表达水平可以反映疾病的严重程度;竹黄颗粒对治疗寻常型银屑病(血热型)疗效显著。

Objective： To research relation between microRNA-146a and PASI index of psoriasis vulgaris （blood heat syndrome） as well as the clinical effect of the Zhuhuang Particles. Methods： Sixty-four cases of patients with psoriasis vulgaris （blood heat syndrome） in this study were randomly divided into two groups, 32 cases in the treatment group, 32 cases in the control group. Zhuhuang Particle and Fufang Qingdai Pill were received respectively for 2 courses, four weeks as a course. Pre-treatment levels of miRNA-146a expression of their lesion area and severity （PASI） index were observed for linear correlation analysis, and the extent of decrease in PASI index was observed after treatment, in order to reflect the clinical efficacy Zhuhuang Particles. Result： Linear correlation analysis results showed that there was a positive correlation between microRNA-146a expression in peripheral blood and PASI index through （r=0.92, P〈0.05）. PASI index decreased in Zhuhuang Particle therapy group compared with in the control group. Conclusion： microRNA-146a was positively correlated with PASI index, which suggested that the serum expression level of MiRNA-146a could indicated severity of the disease. Zhuhuang Particles had a significant effect for the treatment of psoriasis vulgaris （blood heat syndrome）.