芍倍注射液防治疗痔术后并发症的临床疗效观察

Clinical observation of treating hemorrhoid post-operation with Shaobei Injection

目的:观察比较内痔混合痔患者接受芍倍注射液注射和消痔灵注射,两组患者术后3、7d痔核表面糜烂、出血、局部硬结、排尿困难等并发症的发生情况以及两组术后随访半年直肠狭窄、排便困难的发生情况。方法:筛选符合入选条件的内痔、混合痔患者136例,采用随机双盲设计,分为治疗组67例、对照组63例(6例退出),治疗组采用外剥内扎加芍倍注射液注射或芍倍注射液单纯注射;对照组采用外剥内扎加消痔灵注射或单纯消痔灵注射,观察两组治疗后3、7d肛门疼痛程度、痔核黏膜糜烂、出血、局部硬结、排尿困难及随访半年后直肠狭窄、排便困难情况。结果:两组比较患者均治愈出院,平均创口愈合时间治疗组为(12.00±1.76)d,对照组(12.41d±1.46)d,两组比较均无显著差异。并发症分析:治疗后3d及7d,两组在疼痛程度,痔核黏膜表面糜烂、出血、局部硬结、排尿困难方面均有显著差异(P<0.05)。随访半年后,两组在排便困难方面、直肠狭窄方面显著差异(P<0.05)。结论:芍倍注射液组在有效率、注射药量方面与消痔灵组无明显差异,在减少术后痔核表面黏膜糜烂、出血、局部硬结、排尿困难、随访半年直肠狭窄、排便困难方面芍倍注射液组明显优于消痔灵组。

Objective： To observe the complications as elosion of hemorrhoids surface, bleeding, local induration and dysuresia on the 3rd and 7th day of hemorrhoid post-operation, and the incidences of rectostenosis and difficult defecation in half a year of hemorrhoid post-operation, and then compare the above complications between patients with internal hemorrhoids and mixed hemorrhoids in Shaobei Injection treatment group and Xiaozhiling Injection treatment group. Methods： One hundred and thirty-six eligible patients with internal hemorrhoids and mixed hemorrhoids were selected and divided in to treatment group （67 cases） and control group （63 cases） by using randomized double-blind design, with extra 6 patients dropped out. Patients in treatment group treated with external dissection and internal ligation operation combined with Shaobei Injection or Shaobei Injection alone, and patients in control group were treated with external dissection and internal ligation operation combined with Xiaozhiling Injection or Xiaozhiling Injection alone. The complications as erosion of hemorrhoids surface, bleeding, local induration, pain degree of anal and dysuresia on the 3rd and 7th day of treatment and the incidences of rectostenosis and difficult defecation in half a year after treatment of the two groups were observed. Results： Patients in the two groups all cured and left hospital. The average wound healing time of treatment group was （12.00!-_1.76）d, and the average wound healing time of control group was （12.41＋1.46）d, so the difference between the two groups was no significant. On the 3rd day and 7th day, the difference in complications as pain degree, erosion of hemorrhoids surface, bleeding, local induration and dysuresia between the two groups was significant （P〈0.05）. After half a year of follow-up, the difference in rectostenosis and difficult defecation between the two groups was significant （P〈0.05）. Conclusion： The difference in effective rate and injection dosage between Shaobei Injection treatment group and Xiaozhiling treatment group was not significant, and the curative effects of Shaobei Injection in erosion of hemorrhoids surface, bleeding, local induration, dysuresia, rectostenosis and difficult defecation were superior to Xiaozhiling Injection.