nm23基因在原发性乳腺癌组织中的表达及意义

The nm gene Expression and its Clinical Significance in Primary Breast Cancers

【目的】探讨原发性乳腺癌组织中 nm23基因表达及其临床意义。【方法】选取本院2012年1月至2013年12月收治的120例原发性乳腺癌患者为研究对象,采取 SP 法检测癌组织中 nm23基因表达情况,并分析其与临床病理特征的关系。【结果】120例原发性乳腺癌组织中,nm23基因阳性表达率66.7%（80/120）。临床分期中Ⅰ期、Ⅱ期、Ⅲ期、Ⅳ期 nm23基因表达阳性率分别为75.0%（15/20）、70.0%（35/50）、62.5%（26/40）、50.0%（5/10）；肿瘤≤2.0 cm、2.0～5.0 cm、＞5.0 cm 的 nm23基因表达阳性率分别为75.0%（45/60）、67.5%（27/40）、40.0%（8/20）；浸润性癌与非浸润性癌 nm23基因表达阳性率分别为72.2%（65/90）、50.0%（15/30）；淋巴结转移中阴性、0～3个和＞3个 nm23基因表达阳性率分别为75.0%（30/40）、70.0%（35/50）、50.0%（15/30）。nm23基因表达阳性率在临床 TNM 分期、肿瘤大小、病理分型、淋巴结转移中比较具有统计学有意义（P ＜0.05）。【结论】原发性乳腺癌组织中 nm23基因表达与临床分期、肿瘤浸润和转移以及大小有着密切的关系,并可将其作为乳腺癌预后的一个重要参考指标。

[Objective]To investigate the expression and the clinical significance of nm23 gene on primary breast cancers.[Methods]A total of 120 cases of primary breast cancer in our Hospital from January 2012 to December 2013 were enrolled in this study.The nm23 gene expression on breast tumors was detected using SP assay.The clinical patho-logical features and gene expression profile were analyzed.[Results]Among the 120 primary breast carcinoma cases,the o-verall nm23 gene expression rate is 66.7% （80/120）.The expression rates are 75.0% （15/20）,70.0% （35/50）,62.5%（26/40）,50.0% （5/10）in clinical stageⅠ,Ⅱ,Ⅲ,and Ⅳ diseases respectively;nm23 gene expression rate is 75.0% （45/60）,67.5% （27/40）,40.0% （8/20）in tumor ≤2.0 cm,2.0 to 5.0 cm,or 〉 5.0 cm respectively;the expression rate in invasive carcinoma and carcinoma in situ （non-invasive cancer）is 72.2% （65/90）and 50.0% （15/30）;nm23 gene ex-pression positive rates in cases with negative lymph node metastasis,0-3 positive lymph nodes,and more than 3 positive lymph nodes are 75.0 % （30/40）,70.0% （35/50）,50.0% （15/30）.There is a statistically significance of m23 gene ex-pression rate in different clinical TNM stages,tumor sizes,histological types,and lymph node status （P 〈0.05）.[Con-clusion]The expression of nm23 gene in primary breast cancers is closely correlated to the clinical stages,tumor size,in-vasiveness,and lymph node metastatic status of the tumors.Positive expression of nm23 gene on primary breast cancers can be considered as an important negative prognostic factor.