咖啡酸片对肝硬化患者白细胞、血小板计数变化的临床观察

Clinical observation on effect of coffeic acid on leukocyte anal platelet count in patients with cirrhosis

目的观察咖啡酸片对肝硬化患者合并脾功能亢进所致白细胞、血小板数量减少的临床疗效。方法选择肝硬化伴脾功能亢进患者,分为代偿期70例和失代偿期32例两组,均给予咖啡酸片0.3g/次,每日3次口服,共3个月,观察治疗前后患者白细胞、血小板计数变化。结果咖啡酸片可提高代偿期肝硬化及失代偿期肝硬化患者白细胞数,总有效率分别为75.7%(53/70)和71.9%(23/32);也可提高代偿期肝硬化及失代偿期肝硬化患者血小板数,总有效率分别为91.4%(64/70)和84.4%(27/32)。结论咖啡酸片对代偿期、失代偿期肝硬化并脾功能亢进患者的白细胞、血小板计数均有提高作用,尤其代偿期肝硬化患者,疗效更好。

Objective To investigate the CinicaI effect of eaffeic acid tablets（CFA） in thrombocytopenia and leucopenia caused by hypersplenism with liver cirrhosis. Methods 102 patients with liver cirrhosis and hypersplenism were enrolled in this study, including 70 patients with compensated cirrhosis and 32 patients with decompensated cirrhosis. All of the patients were assigned to receive CFA （0.3） tid orally, then the number changes of platelet and leukocyte after 3 months of treatment were evaluated. Results CFA increased the number of leukocytes in 75.5% patients with compensated cirrhosis, while 71.9 % patients with decompensated cirrhosis. We also found that CFA could increase the number of platelets in 91.4% patients with compensated cirrhosis, while 84.4% patients with decompensated cirrhosis. Conclusion CFA could increase the number of leukocytes and platelets in both compensated and decompensated cirrhotic patients, especially in the compensated cirrhotic patients.