细菌整合子中整合酶基因调控的研究进展

Advances in integrase regulations of bacteria-A review

本文基于细菌I型整合子中整合酶与细菌耐药性的密切关系,对影响整合酶基因表达调控的因素,如抗生素、c AMP-CRP途径、Pc-P2结合体、att C位点、一些拟核蛋白以及可变区的长度等,进行了总结分析。为缓解当今社会环境面临的细菌耐药性趋势逐渐加剧的问题提供了新的思路和参考。

Because the integrase of class 1 integron in bacteria has been demonstrated closely relative with antimicrobial resistance,we summarize in this review the discussions on some regulation factors with expression of the integrase,such as antibiotics,carbon catabolite repression（ c AMP-CRP complex）, the promoter of gene cassette variants（ Pc-P2combinations）,att C sites,some nucleotide-associated proteins,and the length of variable region. Furthermore,we also provide knowledge of the regulation mechanism of integrase,as well as insight into controlling the dissemination of antimicrobial resistance in the environments.