吸入性糖皮质激素联合清肺定喘颗粒治疗哮喘(冷哮)的临床研究

The Clinical Research on the Asthma(with Cold) Treatment with Inhaled Corticosteroids and Qingfei Dingchuan Particles

目的观察清肺定喘颗粒在治疗支气管哮喘(冷哮)的临床疗效。方法将符合支气管哮喘急性发作期诊断标准的68位受试者按随机数字表法均分为两组,对照组34例给予雾化吸入布地奈德加多索茶碱片口服;治疗组在雾化吸入布地奈德基础上加服清肺定喘颗粒。两组均以14 d为1个疗程,疗程结束后进行观察指标的比较。结果对照组与治疗组在其临床疗效总有效率分别为85.29%和88.24%,总体疗效相当(P>0.05);两组治疗后其临床症状积分较治疗前差异有统计学意义(P<0.05)。结论清肺定喘颗粒配合吸入性糖皮质激素治疗支气管哮喘急性发作期(冷哮)患者,能够明显降低其临床症状积分和改善肺功能及降低Fe NO浓度。

Objective： To observe the clinical curative effect of Qingfei Dingchuan Particles on treating bronchial asthma （with cold）. Methods： 68 subjects in line with the diagnostic criteria of bronchus asthma acute phase were divided into 2 groups according to random number table method. 34 cases in the control group were treated with liquid atomization inhalation budesonide （Bid） and oral Doxofylline tablets ;the treatment group took Qingfei Dingchuan Particles （Ephedra, Almond, semen tingli, rhizoma belamcandae, Pinellia temata, Aster tatari- cus,flos farfarae, Asarum,Atractylodes,licorice, Campanulaceae, Curculigo, epimedium, ginger）, based on the treatment of the control group. The treatment course of both groups lasted for 14 days. After treatment,the obser- vation index was compared. Results： The total efficiency of the clinical curative effect of the control group and the treatment group were respectively 85.29% and 88.24%. Two groups had no statistical significant difference in the overall curative effect and the total effective rate （P〉 0.05）. Clinical symptom scores were statistically signifi- cant compared with that before treatment（P〉 0.05）. Conclusion： Qingfei Dingchuan Particles, having a good cu- rative effect in treating bronchial acute episodes and non-toxic side effects, can reduce the clinical symptom inte- gral popularization value,improve lung function, and reduce FeNO concentration, easily taken,worth promoting.