PPARγ在阿尔茨海默病中的作用及影响因素研究进展

The role of PPARγ in Alzheimer's disease and its impact factors

阿尔茨海默症(Alzheimer's disease,AD)是一种以记忆丧失和认知衰退为主要临床症状的大脑神经退行性疾病。目前有关AD的病因仍然不明确且临床上无有效的防治措施。PPARγ是一种配体激活型转录因子,在AD的病理过程中扮演着重要角色,可作为神经保护作用靶点;同时许多PPARγ的激动剂己经被证明在AD的细胞和动物模型上具有神经保护作用。文中综述了PPARγ在AD中发挥的作用,以及影响PPARγ活化的因素,特别强调矢车菊素-3-O-葡糖糖苷(Cy3G)在发挥神经保护作用的同时,可能作为神经系统中潜在的PPARγ激动剂。

Alzheimer＇s disease （AD）, is a neurodegenerative disorder of the brain that is characterized by loss of memory and cognitive decline. At present, AD etiology remains unclear and there are no effective prevention and treatment measures in clinical practice. Peroxisome proliferator-activated receptor γ （PPARγ） is a ligand-regulated nuclear hormone receptor. Recent studies showed PPARγ -pathway played an important role in the pathogenesis of AD and some PPARγ agonists have been proven to be neuroproteetive in vitro and in vivo models. This paper reviews the roles of PPARγ and related mechanisms in AD, summarizes affecting factors about PPARγ pathway. Particularly, the effect of cyanidin-3-O-glucoside （Cy3G）, one of the anthocyanidin glycoside forms, is a compound of naturally occurring phenolic compounds, suggesting the neuroprotective effect of Cy3G might be used as a potential natural PPARγ agonist in the nervous system.