423例儿童药品不良反应回顾性分析

Retrospective Analysis of 423 Cases of Adverse Drug Reactions

目的:分析儿童药品不良反应(ADR)发生的规律与特点,为临床用药提出合理化建议与参考。方法:统计、分析我院2013年1月至2014年11月上报的423例ADR报告,包括患儿的年龄、性别、给药方法、药品分类、累及器官或系统、临床症状以及新的严重的ADR。结果:423例ADR报告中,男女比例为1∶0.79,抗菌药物引起ADR共计157例,占37.12%,静脉注射引发的ADR占71.63%,ADR累及皮肤及附件占总例数的83.68%。结论:儿童专科医院更应该加强ADR监管工作,尤其是把握静脉注射抗生素及中药注射剂的使用指征,减少儿童ADR的发生率。

Objective： To analysis the laws characteristics of children’s adverse drug reaction（ ADR）,give reasonable suggestion and reference for clinical medicine in our hospital. Methods： Statistics,analysis of our hospital from January 2013 to November 2014,423 cases of ADR were reported,including the patients’ age,gender,dosing method,drug classification,involving the organs or systems,clinical symptoms and new serious ADR. Results： Four hundred and twenty three cases of adverse reactions were reported,the sex ratio of 1 ∶ 0.79,antibacterial drug adverse reaction caused by a total of 157 cases,accounting for 37. 12% of the total number of cases,intravenous injection of ADR accounted for 71. 63%,accounting for 83. 68% of the total number of cases,involving the skin and accessories accounting for 83.68% of the total number of cases. Conclusion： Children’s hospital should strengthen the ADR monitoring work,especially to grasp the application intravenous antibiotics and the use of Traditional Chinese medicine injections,reduce the incidence of adverse drug reactions in children.