降钙素原和超敏C反应蛋白联合检测在感染性疾病中的应用价值

Application value of combined detection of procalcitonin and high-sensitivity C-reactive protein in the diagnosis of infectious diseases

目的探讨降钙素原(PCT)和超敏C反应蛋白(hs-CRP)联合检测在临床感染性疾病诊断中的应用价值。方法选取2012年6月至2014年12月住院治疗的感染性疾病患者162例,根据病原体分离培养和血清学病毒抗体检测结果将其分为细菌感染组(92例),病毒感染组(70例);另选取同期体检健康者100例设为健康对照组。采用免疫层析法和免疫荧光分析法分别检测血清PCT和hs-CRP水平,并进行比较分析。结果细菌感染组血清PCT和hs-CRP水平均高于健康对照组,差异均有统计学意义(P<0.05);病毒感染组血清PCT和hs-CRP均水平高于健康对照组,但仅hs-CRP比较差异有统计学意义(P<0.05);细菌感染和病毒感染患者PCT和hs-CRP联合检测阳性率高于单项检测(P<0.05)。结论 PCT与hs-CRP可作为细菌感染性疾病的血清标志物,联合检测对感染性疾病的诊断和预后评估具有临床意义。

Objective To explore application value of combined detection of procalcitonin（PCT ） and high‐sensitivity C‐reactive protein （hs‐CRP） in clinical diagnosis of infectious diseases .Methods 162 cases of hospitalized patients with infectious diseases from June 2012 to December 2014 were enrolled in this study and divided into bacterial infection group（92 cases）and viral infection group （70 cases） according to the results of isolation and culture of pathogen and virus antibody detection .Other 100 cases of healthy individuals were selected as healthy control .The serum levels of PCT and hs‐CRP were detected by using immunochroma‐tography and immunofluorescence assay respectively and were statistically analysed .Results The serum levels of PCT and hs‐CRP in the bacterial infection group were higher than those in the healthy control group ,the differences were statistically significant （P〈0 .05） .The serum levels of PCT and hs‐CRP in the viral infection group were higher than those in the healthy control group , but only the difference of hs‐CRP between the two groups was statistically significant（P〈0 .05） .In patients with bacterial infection and viral infection ,the positive rates of combined detection of hs‐CRP and PCT were higher than single detection of hs‐CRP or PCT ,the differences were statistically significant（P〈0 .05） .Conclusion PCT and hs‐CRP could be important serum markers of bacterial infections ,combined detection of the two markers have clinical significance for diagnosing infectious diseases and assessing its prognosis .