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不同年龄段乳腺癌患者临床病理特征分析 被引量:11

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摘要 目的:分析不同年龄段乳腺癌患者的临床病理特征。方法选取563例乳腺癌患者,确诊乳腺癌时年龄≤35岁84例、36~50岁250例、51~64岁194例、≥65岁35例,对不同年龄段患者的临床资料进行回顾性分析。结果与其他年龄段比较,≥65岁者浸润性导管癌、临床分期Ⅰ期、孕激素受体及人表皮生长因子受体2阳性所占比例最低,浸润性小叶癌、T4期、临床分期Ⅳ期所占比例最高,P均<0.05。各年龄段淋巴结转移、雌激素受体及Ki-67表达比较,P均>0.05。结论<65岁的乳腺癌患者肿瘤原发灶小,确诊时分期较早,但病理类型及分子生物学表型较差;≥65岁的乳腺癌患者肿瘤原发灶大,确诊时分期晚,但病理类型及分子生物学表型较好。
出处 《山东医药》 CAS 北大核心 2015年第34期32-33,共2页 Shandong Medical Journal
基金 天津市抗癌重大专项攻关计划(12ZCDZSY16200)
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  • 1Han W,Kang SY.Relationship between age at diagnosis and out- come of premenopausal breast cancer:age less than 35 years is a reasonable cut-off for defining young age-onset breast cancer [J].Breast Cancer Res Treat,2010,119(1):193-200.
  • 2Gnerlich JL,Deshpande AD,Jeffe DB,et al.Elevated breast cancer mortality in women younger than age 40 years compared with older women is attributed to poorer survival in early-stage disease [J].J Am Coll Surg,2009,208(3):341-347.
  • 3Siegel R,Ma J,Zou Z,et al.Cancer statistics,2014[J].CA CancerJ Clin,2014,64(1):9-29.
  • 4Ferlay J,Shin HR,Bray F,et al.Estimates of worldwide burden of cancer in 2008:GLOBOCAN 2008[J].Int J Cancer,2010,127(12):2893-2917.
  • 5Lee SY,Jeong SH,Kim YN,et al.Cost-effective mammography screening in Korea:high incidence of breast cancer in young women[J].Cancer Sci,2009,100(6):1105-1111.
  • 6Li J,Zhang BN,Fan JH,et al.A nation-wide multicenter 10-year(1999-2008)retrospective clinical epidemiological study of female breast cancer in China[J].BMC Cancer,2011(11):364.
  • 7Topps A,Clay V,Absar M,et al.The sensitivity of pre-operative axillary staging in breast cancer:comparison of invasive lobular and ductal carcinoma[J].EurJ Surg Oncol,2014,40(7):813-817.
  • 8Dutra MC,Rezende MA,de Andrade YP,et al.[Immunopheno- type and evolution of breast carcinomas:a comparison between very young and postmenopausal women][J].Rev Bras Ginecol Obstet,2009,31(2):54-60.
  • 9Anders CK,Hsu DS,Broadwater G,et al.Young age at diagnosis correlates with worse prognosis and defines a subset of breast canc- ers with shared patterns of gene expression [J].J Clin Oncol,2008,26(20):3324-3330.
  • 10Goldhirsch A,Winer EP,Coates AS,et al.Personalizing the treat- ment of women with early breast cancer:highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2013[J].Ann Oncol,2013,24(9):2206-2223.

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