摘要
目的:探讨内皮素、降钙素基因相关肽在急性心肌梗死发病中的临床意义。方法:应用放免法同步动态测定急性心肌梗死(AMI)组(n=44)、正常对照组(n=38)的血浆ET、CGRP的浓度水平。结果:AMI组即刻、第1d、第7d ET、CCRP均明显高于AMI恢复期和正常对照组;但ET/CGRP比值明显降低,且ET与CGRP呈显著正相关。至第14d ET、CGRP明显下降,均具有统计学意义。结论:ET与CGRP的动态变化对急性心肌梗死的病理生理过程具有重要的影响。
Objective: To study the clinical significance of plasma ET, CGRP levels in patients with acute myocardial infarction (AMI) .Methods: The morning changes of plasma ET and CGRP levels were measured by radioimmunoassay in 44 patients with acute myocardial infarction (AMI) and 38 normal subjects. Results: During the attack and the 1st and 7th day of AMI the levels of ET and CGRP in AMI group were significantly higher than that in normal group and in AMI group during the recovery period, but the ET/ CGRP ratio was less than that in normal group and the ET level had a parallel relationship with CGRP level. 14th day after treatment the ET and CGRP levels decreased significantly ( P < 0.05 - 0.001) . Conclusion: The imbalance of ET and CGRP level may play a role in pathophysiology and pathogenesis of AMI.
出处
《医学理论与实践》
2002年第8期871-872,共2页
The Journal of Medical Theory and Practice
