灯盏细辛注射液治疗椎基底动脉供血不足临床观察

Clinical Observation of Curative Effect of Lamp Calyx Seoul Wildginger Injection on Patients with Vertebrobasilar Arterial Insufficiency

目的:观察灯盏细辛注射液对椎基底动脉供血不足患者血脂、血液流变学及经颅多普勒(TCD)的影响。方法:100例椎基底动脉供血不足患者随机分成2组:50例灯盏细辛注射液治疗,50例用复方丹参注射液作对照。观察灯盏细辛注射液治疗后血脂、血液流变学及TCD的改善情况。结果:灯盏细辛注射液能明显降低血浆甘油三酯及总胆固醇的水平,高密度脂蛋白水平上升(t=30.12,P<0.01;t=21.5,P<0.01;t=8.81,P<0.01),明显降低血浆粘度、血细胞比容、红细胞聚集指数(t=5.88,P<0.01;t=2.75,P<0.01;t=3.75,P<0.01),并且TCD的平均速度、频谱明显改善。结论:灯盏细辛注射液可降低血脂、血浆粘度,具有活血化瘀,扩张血管,改善微循环及椎基底动脉供血不足的功能,其疗效明显优于丹参注射液,且无明显副反应,是治疗椎基底动脉供血不足的理想药物。

Objective: To observe the effect of lamp calyx seoul wildginger injection (LCSWI) on blood lipids, hemorheology and TCD in patients with vertebrobasilar arterial insufficiency(VAI) .Methods: 100 patients with VAI were divided randomly into two groups,50 cases of the treated group were treated with LCSWI and 50 cases of the control group were treated with salviae miltirrhiza injection (SMI) .The improvement conditions of blood lipids, hemorheology and TCD after treatment with LCSWI were observed. Results: LCSWI could obviously decrease the level of TG and TC, increase the level of HDL (( t = 30. 12, P < 0.01; t = 21.5, P < 0.01; t = 8.81, P < 0.01), reduce plasm viscosity degree, red blood specific volume and ery throcy te aggregation exponent (t = 5.88, P<0.01;t=2.75,P<0.01;t = 3.75,P<0.01), improve average velocity of TCD and spectrum. Conclusion: LCSWI, which can reduce blood lipids ; plasm viscosity degree, expland blood vessel, improve microcirculation and VAI, is an ideal drug in treating VAI. The curative effect of LCSWI is better than that of SMI,moreover it doesn't have obviously side effect.