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桑杞脑康颗粒改善转基因果蝇阿尔茨默病模型学习记忆的作用 被引量：1

Effects of Sangqi Naokang Granules on the Learning and Memory Ability of Transgenic Alzheimer's Disease of Drosophila Model
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摘要 目的观察桑杞脑康颗粒对于阿尔茨海默病(AD)果蝇模型学习记忆能力的影响。方法采用Gal4/USA系统建立Aβ42果蝇模型;连续给药后利用巴普洛夫嗅觉学习实验观察桑杞脑康颗粒对AD果蝇行为的影响。结果桑杞脑康浸膏1.72mg·m L-1、0.172mg·m L-1干预剂量可以显著改善Aβ42果蝇的学习能力(P<0.001),与临床上用于治疗AD的美金刚效果相当(P>0.05)。结论桑杞脑康颗粒具有显著改善Aβ42引起的AD果蝇学习缺陷的作用。 OBJECTIVE To observe the effect of Sangqi Naokang granules on the learning and memory ability of transgenic Alzheimer′s disease of drosophila model.METHODS with an extensively characterized Pavlovian ol-factory aversive conditioning,the effect of feeding Sangqi Naokang in Aβ42-expressing drosophila operated by Gal4/USAsystemwasprobed.RESULTS 1.72mg·mL-1and0.172mg·mL-1SangqiNaokangextractcansignificant-ly improve the learning and memory ability of transgenic Alzheimer′s disease of drosophila model （ P 〈0.001）. CONCLUSION Sangqi Naokang granules can significantly rescue the learning and memory loss induced by Aβ42.
作者 杨巧巧 卿玉玲 桑勤 赵嘉将 秦少容
机构地区 太极医药研究院 太极集团有限公司
出处 《海峡药学》 2015年第8期220-222,共3页 Strait Pharmaceutical Journal
关键词 桑杞脑康颗粒 阿尔茨海默病 Aβ42蛋白 果蝇 Sangqi Naokang Granules Alzheimer′s Disease Drosophila
分类号 R969 [医药卫生—药理学] R282.71 [医药卫生—中药学]
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参考文献10

  • 1重庆大易科技投资有限公司.一种药物组合物及其制备方法和质量控制方法[P].中国专利:2005100707352,2006 -11-22.
  • 2Wang L1,Chiang HC.Epidermal growth factor receptor is a preferred\starget for treating amyloid-β-induced memory loss[J].Proc Natl Acad\sSci USA,2012,109(41):16743-8.
  • 3Tully T,Quinn WG.Classical conditioning and retention in normal and\smutant Drosophila melanogaster[J].J Comp Physiol A,1985,157:263-277.
  • 4Tully T,Boynton SC,et al.Genetic dissection of consolidated memory\sin Drosophila[J].Cell,1994,79:35-47.
  • 5徐金静,方力群,赵春慧,唐浩,高鹏,张双彦.β淀粉样蛋白对阿尔茨海默病转基因果蝇认知功能的影响[J].国际神经病学神经外科学杂志,2013,40(2):101-104. 被引量：11
  • 6Jeibmann A,Paulus W.Drosophila melanogaster as a model organism\sof brain diseases[J].Int J.Mol Sci,2009,10:407-440.
  • 7谭燕,季宇彬,赵简.阿尔茨海默病转基因果蝇模型的研究进展[J].药学学报,2013,48(3):333-336. 被引量：6
  • 8Iijima K,Liu HP,Chiang As,et al.Dissecting the pathological effects\sof human Abeta40 and Abeta42 in Drosophila:a potential model for\sAizheimer's disease[J].Proc Acad Sci USA,2004,101:6623-6628.
  • 9Iijima K,Chiang HC,Hearn SA,et al.Abeta42 mutants with different\saggregation profiles induce distinct pathologies in Drosophila[J].PLoSOne,2008,3:e1703-1703.
  • 10乐卫东,李靓.阿尔采末病模式生物研究进展[J].中国新药与临床杂志,2006,25(9):649-655. 被引量：2

二级参考文献95

  • 1KRAEMER BC, ZHANG B, LEVERENZ JB, et al. Neurodegeneration and defective neurotransmission in a Caenorhabditis elegans model of tauopathy[J]. Proc Natl Acad Sci USA, 2003,100(17) : 9980-9985.
  • 2MIYASAKA T, DING Z, GENGYO-ANDO K, et al. Progressive neurodegeneration in C. elegans model of tauopathy[J]. Neurobiol Dis, 2005, 20(2): 372-383.
  • 3KRAEMER BC, BURGESS JK, CHEN JH, et al. Molecular pathways that influence human tau-induced pathology in Caenorhabditis elegans[J]. Hum Mol Genet, 2006, 15 (9):1483-1496.
  • 4GREEVE I, KRETZSCHMAR D, TSCHAPE JA, et al. Agedependent neurodegeneration and Alzheimer-amyloid plaque formation in transgenic Drosophila[J]. J Neurosci, 2004, 24(16):3899-3906.
  • 5IIJIMA K, LIU HP, CHIANG AS, et al. Dissecting the pathological effects of human Abeta40 and Abeta42 in Drosophila: a potential model for Alzheimer's disease[J]. Proc Natl Acad Sci USA, 2004, 101(17): 6623-6628.
  • 6WITTMANN CW, WSZOLEK MF, SHULMAN JM, et al. Tauopathy in Drosophila: neurodegeneration without neurofibrillary tangles[J]. Science, 2001, 293(5530): 711-714.
  • 7JACKSON GR, WIEDAU-PAZOS M, SANG TK, et al. Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in Drosophila[J]. Neuron, 2002, 34(4): 509-519.
  • 8SHULMAN JM, FEANY MB. Genetic modifiers of tauopathy in Drosophila[J]. Genetics, 2003, 165(3): 1233-1242.
  • 9NISHIMURA I, YANG Y, LU B. PAR-1 kinase plays an initiator role in a temporally ordered phosphorylation process that confers tau toxicity in Drosophila[J]. Cell, 2004, 116(5): 671-682.
  • 10DODART JC, MEZIANE H, MATHIS C, et al. Behavioral disturbances in transgenic mice overexpressing the VT17F betaamyloid precursor protein[J]. Behav Neurosci, 1999, 113 (5) :982-990.

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海峡药学
2015年 第8期

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