间苯三酚与山莨菪碱在泌尿系统冲击波碎石治疗中排石效果和镇痛作用效果比较

Effectiveness comparison between phloroglucinol and anisodamine in the treatment of urolithiasis

目的探讨山莨菪碱与间苯三酚用于泌尿系统结石治疗中排石和镇痛疗效的差异。方法入选100例泌尿系统结石患者,随机分为治疗组和对照组,每组50例。所有患者均使用体外冲击波碎石治疗,治疗组给予间苯三酚静脉滴注,对照组给予山莨菪碱静脉滴注。比较两组患者碎石效率、排石时间和不良反应。结果治疗组患者止痛有效率为94.0%,显著优于对照组的78.0%(P<0.05)。治疗组患者上段、中段、下段输尿管结石和肾盂结石的排石有效率分别为93.3%、58.3%、91.7%和90.9%,对照组分别为61.5%、54.5%、53.8%和53.8%,除中段结石外,治疗组患者排石效果显著改善(P<0.05)。治疗组结石排出时间分别(7.2±2.1)、(9.5±3.2)、(5.1±1.2)和(7.3±2.3)min,对照组分别为(9.6±2.8)、(10.4±3.5)、(8.8±1.6)和(9.8±3.0)min,除中段结石外,治疗组患者结石排出时间显著低于对照组(P<0.01)。治疗组患者无不良反应发生,对照组不良反应发生率为22.0%,差异有统计学意义(P<0.01)。结论间苯三酚应用于泌尿系统结石治疗可以增强排石效果并发挥良好镇痛效果,疗效优于山莨菪碱。

Objective To investigate the effectiveness comparison between phloroglucinol and anisodamine in the treatment of urolithiasis. Methods Total of 100 cases of urolithiasis patients were randomly divided into treatment group and control group, 50 cases in each group. All patients were using extracorporeal shock wave lithotripsy treatment, the control group was given intravenous infusion of anisodamine, the treatment group was given phloroglucinol intravenous drip. The crushed stone, stone expulsion time efficiency and adverse reactions in two groups were compared. Results Pain relief rate in treatment group was 94.0%, which was significantly better than the control group （78.0%, P〈0.05）. In treatment group the upper, middle, lower ureteral calculi and renal pelvis calculi discharge rates were 93.3%, 58.3%, 91.7% and 90.9%, and that in control group were 61.5%, 54.5%, 53.8% and 53.8%, in addition to middle ureteral calculi, patients with gallstone treatment group improved significantly （P 〈 0.05）. The stone discharge time were （7.2 ± 2.1）, （9.5 ± 3.2）, （5.1 ± 1.2） and （7.3 ±2.3） mins in treatment group, which were significantly shorter than that in control group [ （9.6 ± 2.8）, （10.4± 3.5）, （8.8 ± 1.6） and （9.8 ± 3.0） mins] in addition to middle ureteral calculi （P 〈 0.01）. There was no adverse reaction in treatment group ,which was significantly better than the control group （22.0%） （P 〈 0.01）. Conclusion Phloroglucinol used in urinary system stone therapy can strengthen lithecbole effect and play a good analgesic effect, which is better than anisodamine.