阿托伐他汀钙治疗老年脑动脉硬化的临床效果探讨

Clinical efficiency of atorvastatin calcium for senile cerebral arteriosclerosis

目的：探讨阿托伐他汀钙治疗老年脑动脉硬化的临床效果。方法选取于2012年12月至2014年12月期间入住海南医学院附属医院的124例老年脑动脉硬化患者进行分析。随机将其分为试验组和对照组（各62例），对照组采用常规方法进行治疗，试验组在对照组的基础上加用阿托伐他汀钙进行治疗；治疗6个月后，观察两组患者的血脂水平、颅内动脉弹性指标、颈动脉硬化斑块大小及脑血管疾病的发生情况等。结果两组患者治疗后的血脂水平、颅内动脉弹性指标、颈动脉硬化斑块大小均较治疗前有所改善，差异具有统计学意义（P＜0.05）；治疗后试验组的血脂水平、颅内动脉弹性指标、颈动脉硬化斑块大小明显优于对照组，差异具有统计学意义（P＜0.05）。试验组的总有效率（98.4%）明显高于对照组（80.6%），差异具有统计学意义（χ2＝5.436，P＜0.05）；试验组的脑血管疾病发生率（3.2%）明显低于对照组（16.1%），差异具有统计学意义（χ2＝5.324，P＜0.05）。结论老年脑动脉硬化患者采用阿托伐他汀钙治疗可明显改善患者的症状，对减少脑血管疾病的发生具有重要的临床意义。

ObjectiveTo evaluate the clinical efficiency of atorvastatin calcium in the treatment of senile cerebral arteriosclerosis. Methods A total of 124 elderly patients with cerebral arteriosclerosis admitted in our hospital from December 2012 to December 2014 were subjected in this study. They were randomly divided into test group and control group （n=62）. The control group was given conventional treatment, and the test group was administered by atorvastatin calcium besides of conventional treatment for 6 months. Blood lipids, intracranial artery elasticity index, size of carotid artery plaque and incidence of cerebrovascular diseases were measured and compared between the 2 groups.Results The blood lipids, intracranial artery elasticity index, and size of cerebral artery plaque were obviously improved in the 2 groups after treatment when compared with before the treatment （P〈0.05）, and those in the test group were more significant than in the control group （P〈0.05）. The total effective rate was 98.4% in the test group, remarkably higher than that of the control group （80.6%,χ2=5.436,P〈0.05）. The incidence of cerebrovascular disease was markedly lower in the test group than in the control group （3.2%vs 16.1%,χ2=5.324,P〈0.05）.Conclusion Atorvastatin calcium effectively attenuates the symptoms in the elderly patients with cerebral arteriosclerosis, and reduces the occurrences of cerebrovascular diseases.