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植入物内固定四肢长管状骨骨折:骨折愈合与血清瘦素的变化 被引量:3

Correlation between serum leptin level and healing of long tubular fractures of the limbs after internal fixation
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摘要 背景:内固定后四肢骨折不愈合是骨折后最常见的并发症之一,影响骨折愈合的因素较多,近年来有学者研究发现血清瘦素可能参与骨折愈合过程中多种代谢的调节。目的:分析内固定手术治疗四肢长管状骨骨折,患者血清瘦素水平变化与骨折愈合的关系。方法:选择四肢长管状骨骨折的患者60例,根据内固定后8个月骨折愈合情况分为骨折愈合组30例和骨折不愈合组30例,另取30例健康志愿者为正常对照组。分别于内固定前后抽取患者外周静脉血,采用双抗体夹心酶联免疫吸附试验(ELISA)检测血清瘦素水平的变化。结果与结论:骨折愈合组和骨折不愈合组患者内固定前后血清瘦素水平均高于正常对照组(P<0.05);骨折愈合组高于不愈合组(P<0.05)。骨折愈合组内固定前后血清瘦素水平差异无显著性意义;骨折不愈合组内固定后血清瘦素水平显著高于内固定前(P<0.05)。结果提示瘦素可能在骨折愈合过程有一定影响。 BACKGROUND: After internal fixation, limb fracture nonunion is the most common complication. Many factors affect fracture healing, but in recent years researchers have found that serum leptin may be involved in the process of fracture healing to regulate a variety of metabolisms. OBJECTIVE: To analyze the relationship between the changes of serum leptin and fracture healing in patients with long tubular fracture of the limbs after internal fixation.METHODS: Sixty patients with long tubular bone fracture who underwent internal fixation treatment were selected, and divided into two groups, union group (n=30) and nonunion group (n=30), according to the degree of fracture healing at 8 months after operation. Another 30 healthy volunteers served as normal control group. Peripheral blood samples were extracted before and after internal fixation to detect the changes in serum leptin levels using ELISA.RESULTS AND CONCLUSION: Preoperative serum leptin level was higher in the union group and nonunion group than the normal control group as well as higher in the union group than the nonunion group (P 〈 0.05). There was no difference in the serum leptin levels in the union group before and after operation, but the nonunion group had a higher preoperative serum leptin level than the postoperative level. These findings indicate that the serum leptin may have an influence on fracture healing.
出处 《中国组织工程研究》 CAS 北大核心 2015年第33期5249-5253,共5页 Chinese Journal of Tissue Engineering Research
基金 济宁市科技局科技项目计划(济科字【2011】57号)~~
关键词 瘦素 四肢 骨折 不愈合 组织构建 骨组织工程 长管状骨 骨折 骨折不愈合 Leptin Extremities Fractures, Ununited
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