摘要
2,6-二氯烟酸经过酰氯化、缩合后,再与2-氨基噻唑缩合、环化得到关键中间体7-氯-4-氧代-1-(2-噻唑基)-1,4-二氢-1,8-萘啶-3-羧酸乙酯,中间体再经过缩合、水解得到Voreloxin,总收率为18.9%。
The key intermediate ethyl 7-chloro-4-oxo-1-（thiazol-2-yl）-1,4-dihydro-1,8-naphthyridine -3-Carboxylate,which was synthsized from 2,6-dichloronicotinic acid via chlorination, condensation,condensation and cyclization, was then used to synthesis Voreloxin through condensation and hydrolysis with a total yield of 18.9 %.
出处
《广东化工》
CAS
2015年第17期68-68,67,共2页
Guangdong Chemical Industry
关键词
萘啶酸
Voreloxin
合成
naphthyridine carboxylic acid
voreloxin
synthesis
