抗抑郁药物治疗肠易激综合征的研究进展

Advances in Study on Antidepressants in Treatment of Irritable Bowel Syndrome

肠易激综合征(IBS)是常见的功能性胃肠病之一,严重影响患者生活质量。目前IBS的发病机制尚未明确,内脏敏感性增高、中枢痛觉异常可能参与发病过程。抗抑郁药物可改善IBS患者腹痛、腹部不适、精神障碍、排便异常,提高患者生活质量。本文就抗抑郁药物治疗IBS的研究进展作一综述。

Irritable bowel syndrome（IBS）is one of the most common functional gastrointestinal disorders,which severely affects the life quality of patients. Currently,the pathogenesis of IBS has not yet been clarified. Visceral hypersensitivity and central algesia abnormality may be involved in the pathogenesis of IBS. Antidepressants can improve abdominal pain,abdominal discomfort,mental disorders and abnormal defecation and enhance the quality of life. This article reviewed the advances in study on antidepressants in treatment of IBS.