维生素K参与骨代谢研究进展

Advances in studies of vitamin K in bone metabolism

维生素K1(vitamin K1,VK1)和维生素K2(vitamin K2,VK2)是自然存在的维生素K(vitamin K,VK)的两种主要结构,除参与肝脏凝血因子的合成,还在骨组织代谢中发挥着重要作用。细胞及动物实验均发现VK能过促进成骨过程,抑制骨吸收,并在临床应用于骨质疏松症的治疗。其作用机制除VK促进骨钙素等成骨相关蛋白的γ-羧化外,还可激活类固醇异生物受体,诱导成骨相关基因的表达。另外,microRNA-133a同时参与了VK的代谢过程及骨代谢过程,可能是VK调节骨代谢的一个重要途径。

Vitamin K1 and vitamin K2 are two structures of vitamin K（ VK） in nature,besides the action in the coagulation factors synthesis in the liver,they also play an important role in bone metabolism. In vitro and animal experiments indicted VK can promote bone formation and inhibit bone resorption. VK has achieved great success for treatment of osteoporosis and prevention for osteoporotic fracture clinically. The mechanism of these actions include the participation of gamma carboxylation of the VK-dependent proteins such as osteocalcin and the induction of gene expression through the activation of steroid xenobiotic receptor. Otherwise,microRNA-133 a may be an important pathway of these actions.