钟控基因PER1、PER2在乳腺癌中的表达及临床意义

Expression and clinical significance of clock genes PER1,PER2 in breast cancer

目的:研究钟控基因PER1、PER2在乳腺癌中的表达,明确时钟基因表达在乳腺癌中的作用。方法:取60例乳腺癌患者癌组织和癌旁组织,分别用免疫组化办法检测PER1、PER2基因蛋白表达,与病理和临床结果进行统计学分析。结果:PER1、PER2基因在乳腺癌细胞和癌旁组织中阳性表达率有显著差异(P<0.01)。乳腺癌PER1蛋白表达和ER、PR、c-erb B2表达、组织分级有显著相关性,和年龄、肿瘤大小和分期无相关性。PER2表达和c-erb B2、组织分级有显著相关性,和年龄、ER、PR、肿瘤大小和分期无相关性。结论:钟控基因PER1、PER2表达缺失和乳腺癌发生有关,在乳腺癌发生过程中具有重要作用。

Objective:To investigate the gene clocked PER1,PER2 expression in breast cancer and its clinical significance in breast cancer.Methods:All 60 cases of breast cancer patientswere detected by immunohistochemical methods to confirm PER1,PER2 protein gene expression inbreast cancer tissues and adjacent tissues,and pathological and clinical results were statistically analyzed.Results:Expression of PER1,PER2 gene in breast cancer cells and ad-jacent tissues were significantly different (P <0.01).PER1 protein expression in breast cancer was significantly cor-related with ER,PR,c -erbB2 expression,histological grade,not correlated with age,tumor size and stage.PER2 pro-tein expression in breast cancer was significantly correlated with c -erbB2,histological grade,not correlated with age, tumor size and stage age,ER,PR,tumor size and stage.Conclusion:Lost of clock gene PER1,PER2 expression has an important role in the development of breast cancer.