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FAP在大肠癌中表达的临床病理意义 被引量：2

The clinical pathological implication of FAP expression in colorectal carcinoma and their significances
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摘要 目的:探讨人大肠癌组织中FAP表达与其临床病理特征的关系。方法:采用免疫组化EN法检测1 4 5例大肠癌组织中FAP的表达。结果:FAP半定量计数、表达浓度与肿瘤分期呈正相关(P=0.02,P=0.01),即在临床分期高的肿瘤组织中,FAP表达的量及浓度都显著增高;FAP染色与肿瘤分级之间没有明显的相关性(P>0.05)。结论:FAP高表达可能与大肠癌的浸润生长及转移有密切关系。 Objective:To investigate the expression of FAP in human colorectal carcinoma and the relationship be-tween the expression and clinicopathological features.Methods:The expression of FAP was detected by immunohisto-chemical EN technique in 145 cases of colorectal carcinoma.Results:Stromal FAP intensity and semiquantitative a-nalysis were positively correlated to cancer stage(P <0.05).There was no correlation of FAP staining with tumor grade.Conclusion:The expression of FAP in colorectal carcinoma is related with tumor aggressiveness and metasta-sis.Detection of FAP expression might be helpful in the evaluation of the prognostic factors in patients with colorectal carcinoma.
作者 王岩 聂明豪 卢艳红 王锐 李晋 杨彬 张海洋 夏明阳 李秀荣
机构地区 黑龙江省医院病理科
出处 《现代肿瘤医学》 CAS 2015年第20期2979-2981,共3页 Journal of Modern Oncology
基金 黑龙江省卫生厅基金项目(编号:2012-347)
关键词 大肠癌 临床病理 colorectal carcinoma,FAP,CAFs,clinical pathological implication
分类号 R735.3 [医药卫生—肿瘤]
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参考文献12

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共引文献6

同被引文献29

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现代肿瘤医学
2015年 第20期

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