血清中Ang-2和VEGF在骨肉瘤中的表达和意义

The expression and significance of VEGF and Ang- 2 in serum of osteosarcoma patients

目的:探讨骨肉瘤患者血清中血管生成素-2(Ang-2)与血管内皮生长因子(VEGF)的含量和临床意义。方法:收集40例骨肉瘤患者和健康志愿者的血清,采用ELISA方法检测血清中Ang-2和VEGF的含量,并分析其与临床病理资料和预后的相关性。结果:骨肉瘤患者血清中VEGF(1234.6±824.5)pg/ml和Ang-2(1035.5±590.2)pg/ml的含量明显高于正常对照组血清中VEGF(334.6±104.2)pg/ml和Ang-2(460.3±120.6)pg/ml的含量(P<0.01)。血清VEGF和Ang-2的含量与骨肉瘤的大小、分期及肺内转移明显相关(P<0.01)。血清中Ang-2和VEGF高表达的患者的总生存时间明显低于低表达患者(P<0.01)。结论:Ang-2和VEGF与骨肉瘤的发展和预后密切相关,可能成为骨肉瘤预后判断的标志物。

Objective:To investigate the expression and significance of vascular endothelial growth factor(VEGF) and angiopoietins -2(Ang -2)in osteosarcoma patients.Methods:The serum levels of VEGF and Ang -2 in 40 ca-ses of patients with osteosarcoma were detected by ELISA.Their relations with the pathological features and prognosis were analyzed.Results:The serum levels of VEGF and Ang -2 were up -regulated in osteosarcoma patients as com-pared with control group (P <0.01).The serum levels of VEGF and Ang -2 in osteosarcoma patients were associated with tumor size,lung metastasis and stages (P <0.01).Over survival in low serum levels of VEGF or Ang -2 were longer than those in high serum levels (P <0.01).Conclusion:The serum levels of VEGF or Ang -2,correlated with the development and metastasis of the osteosarcoma,may be a valuable parameter for prognostic of osteosarcoma.