桂林市流浪精神病患者HIV、HBV、HCV和梅毒螺旋体感染的血清学调查

Serological investigation of HIV,HBV,HCV and TP infections in wandering patients with mental disorders in Guilin city

目的:调查2013年桂林地区流浪精神病患者人类免疫缺陷病毒(HIV)、乙肝病毒(HBV)、丙肝病毒(HCV)及梅毒螺旋体(TP)感染情况。方法:用酶联免疫吸附试法(ELISA)检测流浪精神病患者血HIV抗体(抗-HIV)、HBV表面抗原(HBs Ag)、HCV抗体(抗-HCV)与TP抗体(抗-TP)表达情况,并与非流浪精神病患者作比较。结果:流浪精神病患者抗-HIV、HBs Ag、抗-HCV与抗-TP阳性率分别为0.78%、6.20%、1.55%和6.98%;非流浪精神病患者对应数值分别为0.04%、12.61%、0.82%和0.53%。两组患者HBs Ag阳性率和抗-TP阳性率有统计学差异(P<0.05);抗-HIV与抗-HCV阳性率两组患者无统计学差异(P>0.05)。各指标阳性率在流浪组男、女性别中无统计学差异(P>0.05)。结论:流浪精神病患者人类免疫缺陷病毒(HIV)、乙肝病毒(HBV)、丙肝病毒(HCV)及梅毒螺旋体(TP)均有感染,其中以HBV与TP感染为主;流浪精神病患者是TP感染高危人群;流浪精神病患者4种传染病的感染分布并无性别差别。应在该人群中积极进行传染病筛查检验,尽早发现与隔离并及时治疗。

Objective: To investigate human immunodeficiency virus ( HIV), hepatitis B virus ( HBV), hepatitis C virus (HCV) and treponema pallidum (TP) infections in wandering patients with mental disorders in Guilin city. Methods: The enzyme-linked immuno sorbent assay (ELISA) was used to detect expression of HIV antibody (anti-HIV), HBV surface antigen (HbsAg), HCV antibody (anti-HCV) and TP antibody (anti-TP) in the wandering mental patients, and the results were compared with those in the non-wandering mental patients in Guilin Mental hospital in 2013. Results: The positive rates of anti-HIV, HbsAg, anti-HCV and anti-TP in the wandering mental patients were 0. 78% , 6. 20% , 1. 55% and 6. 98% , respectively, and those in the non-wandering mental patients were 0. 04% , 12. 61% , 0. 82% and 0. 53% . There were significant differences in the HbsAg and anti-TP positive rates between the two group (P<0. 05); however, there were no significant differences in the anti-HIV and anti-HCV positive rates (P>0. 05). There were no significant differences in any positive rate in the wandering mental patients group between different gender (P>0. 05). Conclusions: All four infections especially HBV and TP are observed in the wandering mental patients, who are high-risk population of TP. There are no significant differences of distribution of four infections between genders; therefore, serum screening, in-sulation and necessary treatment should be proceed to them.