摘要
目的探明miR-335在口腔鳞状细胞癌组织中的表达异常情况。方法采用qRT-PCR分别检测25例人口腔鳞状癌细胞及相应邻近正常黏膜组织中miR-335的表达情况,对miR-335在口腔鳞状细胞癌及相应邻近正常黏膜组织中的表达情况进行比较。结果 miR-335在口腔鳞状细胞癌中的表达显著低于其癌旁正常黏膜组织(P<0.05)。结论 miR-335在舌鳞癌中呈低表达,有可能在口腔鳞状细胞癌的发生、发展起重要作用。
Objective To verify the expression variation of miR -335 in the oarl squamous cell carcinoma( OSCC ) .Methods MiR -335 of 25 cases of OSCC and corresponding adjacent normal tissues which were detected with Real-time quantitative PCR were compared.Results The expression of miR-335 in TSCC was significantly lower than its expression in corresponding adjacent normal tissues (P<0.05).Conclusion MiR-335 expression decreased significantly in TSCC.MiR-335 may play an important role in the occurrence and development of OSCC.
出处
《广东微量元素科学》
CAS
2015年第9期30-33,共4页
Trace Elements Science
基金
番禺区科技和信息化局支持项目2014-203-43
