美沙拉嗪联合益生菌治疗溃疡性结肠炎疗效分析

Clinical Observation of Mesalazine Combined With Probiotics in Treatment of Ulcerative Colitis

目的探讨美沙拉嗪联合益生菌治疗溃疡性结肠炎的临床疗效。方法选取广东省英德市中医院收治的64例溃疡性结肠炎患者作为研究对象,按照随机数字法分成两组,对照组32例患者给予单独的美沙拉嗪进行治疗;研究组32例患者给予美沙拉嗪联合益生菌治疗,比较分析两组的临床疗效与复发情况。结果研究组患者的总有效率为93.75%,对照组患者的总有效率为71.88%,研究组的临床疗效明显好于对照组(P<0.05):两组患者在治疗后的血清C-蛋白水平均有所下降,而研究组患者的下降程度明显高于对照组(P<0.01);研究组中患者复发率为12.50%,对照组患者复发率为34.38%,两组的差异具有统计学意义(P<0.05)。结论相比单纯使用美沙拉嗪,采用美沙拉嗪联合益生菌治疗溃疡性结肠炎的临床疗效更为显著,治疗后复发率低,具有临床推广使用价值。

Objective To investigate clinical efficacy of mesalazine combined with probiotics in treatment of ulcerative colitis.Methods 64 patients with ulcerative colitis in our hospital were selected as study group and divided into the control group (32), treated by mesalazine and the study group(32), treated by mesalazine combined with probiotics.The clinical efficacy and relapse of two groups were observed.Results The total effective rate of the study group (93.75%) was significantly higher than that of the control group (71.88%) ( P<0.05 ).Serum C-protein levels of the study group was significantly lower than that of the control group ( P <0.01 ).The recurrence rate of the study group ( 12.50%) was significantly lower than that of the control group ( 34.38%) ( P <0.05 ).Conclusion Compared simply using the mesalazine, mesalazine combined with probiotics in treatment of ulcerative colitis has curative effect, low recurrence rate after treatment.