肛周坏疽性脓皮病

A csae of perianal pyoderma gangrenosum

报告1例坏疽性脓皮病(PG)。患者男,77岁。肛周痛性溃疡5个月。皮损组织病理检查:局部表皮缺失,残留表皮棘细胞间水肿,真皮浅层、中层血管周围密集淋巴细胞、组织细胞及中性粒细胞浸润。直接免疫荧光检查:表、真皮交界基膜区C3颗粒状沉积,真皮血管壁明显C3沉积,Ig G及Ig A阴性。诊断:PG。

A csae of pyoderma gangrenosum is reported. A 77-year-old male presented with painful ulcer around the anus for 5 months. Histopathology showed absence of focal epidermis, edema between the residual epidermal spinous cells, neu- trophils, lymphocytes and histocytes densely infiltrated around the blood vessels of superficial and mid dermis. Direct im- munofluorescence showed intense fluorescence of C3 at the dermal blood vessel walls and granular fluorescence of C3 at the basement membrane zone, IgG and IgA were all negative. The diagnosis was pyoderma gangrenosum.