斑马鱼视网膜再生研究进展

Retinal regeneration in Zebrafish

哺乳动物视网膜损伤后仅有非常有限的自我修复能力。与哺乳动物不同,硬骨鱼类如斑马鱼的视网膜则具有旺盛的再生能力。斑马鱼视网膜损伤后,能够再生其丢失的所有类型的神经元和胶质细胞,并恢复大部分视力。研究表明,斑马鱼视网膜再生的细胞来源是Müller细胞。近年来,关于斑马鱼视网膜Müller细胞去分化及其增殖的分子机制和信号通路的研究取得了许多新的进展。我们就斑马鱼视网膜再生的研究历史、损伤模型和再生细胞来源以及调控的分子机制等做一综述。

After retinal injury or disease, mammals exhibit very limited capacity to repair a damaged retina. In contrast, teleost fish such as Zebrafish mount a robust regenerative response that recovers all types of lost neurons and glia and restores visual function. The source of ceils responsible for this regeneration has been identified as MOiler glia. Recent studies have revealed many important signaling and molecular mechanisms regulating MOiler glia dedifferentiation and proliferation. In this review, we summarize the history of retinal regeneration research, models of injury, source of cells for regeneration, and its underlying molecular mechanisms.