阿司匹林用于心血管疾病一级预防的专家建议被引量：17

Expert advice on usage of aspirin for the primary prevention of cardiovascular disease

导出

摘要阿司匹林用于心血管病一级预防严重不足,主要原因是缺乏简便准确的人群筛选标准和使用安全性。本文汇集多学科专家共同讨论,专家建议以引起血管内皮损伤的危险因素作为简要的划分方法,对整体危险因素进行有效管理;在长期使用前进行出血风险评估,增加阿司匹林一级预防心血管病的临床净获益。 The usage of aspirin for the primary prevention of cardiovascular disease is seriously insufficient now.The main reasons of which are the lack of simple and accurate population screening criteria as well as the safety issue.Based on the suggestion from multi-disciplinary experts,the risk factors for the vascular endothelial injury are proposed to be simple criteria for the evaluation of high risk population.While,bleeding risk assessment before long term aspirin usage could add net clinical benefit on the primary prevention of cardiovascular disease.

作者廖玉华杨天伦高传玉郭涛徐新娟周晓芳刘劲松文重远郑强荪

机构地区华中科技大学协和医院心内科中南大学湘雅医院心内科河南省人民医院心内科昆明医科大学第一附属医院心内科新疆医科大学第一附属医院心脏中心四川省人民医院干部医疗科华中科技大学协和医院消化内科武汉大学人民医院内分泌科第四军医大学唐都医院心内科

出处《临床心血管病杂志》 CAS CSCD 北大核心 2015年第9期919-921,共3页 Journal of Clinical Cardiology

关键词阿司匹林血管内皮损伤心血管病一级预防 aspirin vascular endothelial injury cardiovascular disease primary prevention

分类号 R541.4 [医药卫生—心血管疾病]

引文网络
相关文献

参考文献12

1杨兆军,单忠艳,田浩明,翁建平,周智广,杨文英.中国四省市阿司匹林预防心血管疾病用药现状调查[J].中华糖尿病杂志,2011,3(1):22-26. 被引量：28
2VANDVIK P O, LINEOFF A M, GORE J M, et al. Primary and secondary prevention of cardiovascular disease: Antithrombotic Therapy and Prevention of Thrombosis,9th ed : American College of Chest Physi- cians Evidence-Based Clinical Practice Guidelines [J]. Chest, 2012, 141: e637S--e668S.
3HALVORSEN S, ANDREOTTI F, TEN BERG J M, et al. Aspirin therapy in primary cardiovascular disease prevention: a position paper of the European Society of Cardiology working group on thrombosis [J]. J Am Coll Cardiol, 2014, 64: 319--327.
4刘静,赵冬,王薇,吴桂贤,曾哲淳,刘军,秦兰萍,孙佳艺,吴兆苏.中国多省市心血管病危险因素队列研究与美国弗莱明翰心脏研究结果的比较[J].中华心血管病杂志,2004,32(2):167-172. 被引量：51
5廖玉华.心血管疾病一级预防中阿司匹林作用机制的研究进展[J].中华内科杂志,2013,52(10):878-879. 被引量：13
6CAPRIE STEERING COMMITTEE. A randomised,blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE) [J]. Lancet, 1996, 348, 1329--1339.
7SEREBRUANY V L, MALININ A I, EISERT R M, et al. Risk of bleeding complications with antiplatelet agents: meta-analysis of 338,191 patients enrolled in 50 randomized controlled trials FJ]. Am J Hematol, 2004, 75: 40--47.
8DAMMANN H G, BURKHARDT F, WOLF N. Enteric coating of aspirin significantly decreases gas- troduodenal mucosal lesions [J]. Aliment Pharmacol Ther, 1999, 13: 1109--1114.
9YUSUF S, ZHAO F, MEHTA S R, et al. Effects of clopidogrel in addition to aspirin in patients with a- cute coronary syndromes without ST-segment eleva- tion [J]. N Engl J Med, 2001, S45: 494--502.
10DIENER H C, BOGOUSSLAVSKY J, BRASS L M, et al. Aspirin and clopidogrel compared with clopi- dogrel alone after recent ischaemic stroke or transient ischaemic attack in high-risk patient (MATCH) : ran- domized, double-blind, placebo-controlled trial [J]. Lancet, 2004, 364: 331--337.

二级参考文献26

1Khan Q,Mehta JL. Relevance of platelet-independent effects ofaspirin to its salutary effect in atherosclerosis-related evens.J Atheroscler Thromb,2005 ,12 : 185 -901.
2Bousser MG,Amarenco P,Chamorro A, et al. Terutroban versusaspirin in patients with cerebral ischaemic events ( PERFORM) : arandomised, double-blind, parallel-group trial. Lancet, 2011 ,377:2013-2022.
3Monobe H, Yamanari H, Nakamura K,et al. Effects of low-doseaspirin on endothelial function in hypertensive patients.Clin Cardiol,2001,24:705-709.
4Magen E, Viskoper JR, Mishal J,et al. Effects of low-dose aspirinon blood pressure and endothelial function of treated hypertensivehypercholesterolaemic subjects. J Hum Hypertens, 2005 ,19 : 667-673.
5Ridker PM, Cushman M, Stampfer MJ, et al. Inflammation,aspirin,and the risk of cardiovascular disease in apparentlyhealthy men. N Engl J Med, 1997 ,336 : 973-979.
6Weber C,Erl W, Pietsch A, et al. Aspirin inhibits nuclear factor-kappa B mobilization and monocyte adhesion in stimulated humanendothelial cells. Circulation, 1995 ,91 : 1914-1917.
7Chiang N,Serhan CN. Aspirin triggers formation of anti-inflammatory mediators : New mechanism for an old drug.Discov Med,2004,4:470475.
8Cyrus T, Sung S,Zhao L,et al. Effect of low-dose aspirin onvascular inflammation, plaque stability, and atherogenesis in low-density lipoprotein receptor-deficient mice. Circulation, 2002,106:1282-1287.
9Giles TD, Materson BJ, Cohn JN, et al. Definition andclassification of hypertension : an update. J Clin Hypertenst Greenwich) , 2009 ,11 :611-614.
10Paneni F,Beckman JA,Creager MA,et al. Diabetes and vasculardisease : pathophysiology,clinical consequences,and medicaltherapy : part I [J/OL]. Eur Heart J, 2013 [ 2013 -09 -02]. http : //eurheartj, oxfordjoumals. org/content/early/2013/05/13/eurheartj. ehtl49. full, pdf + html.