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微小核糖核酸与干细胞移植治疗心肌梗死的研究进展 被引量:3

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摘要 微小核糖核酸(miRNAs)是一种内源性非编码调控单链小分子核糖核酸,可通过与目标信使核糖核酸(m RNA)结合,调控基因的转录后翻译过程。有研究显示miRNAs参与修复受损心肌。此外,越来越多的研究发现不同的miRNAs可参与干细胞功能调控,调节干细胞存活、迁移、分化等过程,进而通过改善移植干细胞命运,提高心肌梗死后心功能。本文旨在对miRNAs与干细胞移植治疗心肌梗死的研究现状及所面临的问题进行综述。
作者 王艳 石蓓
出处 《中国循环杂志》 CSCD 北大核心 2015年第9期916-918,共3页 Chinese Circulation Journal
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参考文献35

  • 1van der Bogt KE, Sheikh AY, Sehrepfer S. et al. Comparison of different adult stem cell types for treatment of myocardial isvhemia. Circulation, 2008, 118: S121-S129.
  • 2Janssens S, Dubois C, Bogaert J, et al. Autologous bone marrow- derived stem-cell transfer in patienls with ST-segment elevati,m myocardial infarction: double-blind, randomized controlled trial. Lancet, 2006, 367:113-121.
  • 3Hare JM, Traverse JH, Henry TD, el al. A randomized, double-Dlind, placebo-controlled, dose-escalation study of intravenous aduh human mesenehymal stem cells( prochymal )after acute myocardial infaretion. J Am Coll Cardiol, 2009, 54: 2277-2286.
  • 4Ellison GM, Vicinanza C, Smith A J, et al. Aduh c-kitpos cardiac stem c;-lls are necessary and sufficient for funeti.nal cardiac regeneration and Repair. Cell, 2013, 8: 827-842.
  • 5Chugh AR, Beache GM, Loughran JH, el al. Administratitm of cardiac stem cells in patients with ischemic cardiomyopalhy: the SC1PIO trial: surgical aspects and interim analysis of myocardial function and viability by magnelic resonance. Circulation, 2012, 126: S54-S64.
  • 6Bolli R, Chugh AR, D' Amario D, et al. Cardiac stem cells in patients wilhischaemic cardiomyopalhy (SCIPIO): initial restllls of a randomized phaselrial. Lancet, 2011,378: 1847-1857.
  • 7van Berlo JH, Kanisicak O, Maillet M, el al. c-kil+cells minimally contFih cardiomyocytes to the heart. Nature, 2014, 509: 337-345.
  • 8Lee RC, Feimbaum RL, Ambros V, et al. The Gelegans heterochronic gene lin-4 encodes snmll RNAs with anlisense complementarily to lin-14. Cell, 1993, 75: 843-854.
  • 9Hunlzinger E,Izaurralde E. Gene silencing by miero RNAs: contrihulicms of Iranstational repression and rnRNA decay. Nat Rev Genet, 2011, 12:99-110.
  • 10Barrel DP. MicroRNAs: genomies, Diogenesis, mechanism, and function. Cell, 2004, 116: 281-297.

二级参考文献54

  • 1Zhao Y,Samal E,Srivastava D.Serum response factor regulates a muscle-specific microRNA that targets Hand2 during cardiogenesis.Nature,2005,436:214-220.
  • 2Ajay SS,Athey BD,Lee I.Unified translation repression mechanism for microRNAs and upstream AUGs.BMC Genomics,2010,11:155.
  • 3Thum T,Gross C,Fiedler J,et al.MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts.Nature,2008,456:980-984.
  • 4Roy S,Khanna S,Hussain SR,et al.MicroRNA expression in response to murine myocardial infarction:miR-21 regulates fibroblast metalloprotease-2 via phosphatase and tensin homologue.Cardiovasc Res,2009,82:21-29.
  • 5van Rooij E,Sutherland LB,Thatcher JE,et al.Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis.Proc Natl Acad Sci USA,2008,105:13027-13032.
  • 6Yang B,Lin H,Xiao J,et al.The muscle-specific microRNA miR-l regulates cardiac arrhythmogenic potential by targeting GJAI and KCNJ2.Nat Med,2007,13:486-491.
  • 7Lu Y,Zhang Y,Shan H,et al.MicroRNA-1 downregulation by prolranolol in a rat model of myocardial infarction:a new mechanism for ischaemic cardioprotection.Cardiovasc Res,2009,84:434-441.
  • 8Bostjancic E,Zidar N,Stajner D,et al.MicroRNA miR-1 is up-regulated in remote myocardium in patients with Myocardial Infarction.Folia Biol(Praha),2010,56:27-31.
  • 9Xiao J,Luo X,Lin H,et al.MicroRNA miR-133 represses HERG K'channel expression contributing to QT prolongation in diabetic hearts.Journal of Bioligical Chemistry,2007,282:12363-12367.
  • 10Shi B,Guo Y,Wang J,et al.Altered expression of microRNAs in the myocardium of rats with acute myocardial infarction.BMC Cardiovasc Disord,2010,10:11.

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  • 1Roger VL, Go AS, Lloyd-Jones DM, et al. American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Executive summary: heart disease and stroke statistics-2012 update: a report from theAmerican Heart Association. Circulation, 2012, 125: 188- 197.
  • 2Loyer X, Vion AC, Tedgui A, et al. Microvesicles as cell-cell messengers in cardiovascular diseases. Circ Res, 2014, 114: 345-353.
  • 3Johnstone RM, Adam M, Hammond JR, et al. Vesicle formation during reticulocyte maturation. Association of plasma membrane activities with released vesicles (exosomes). J Biol Chem, 1987, 262:9412-9420.
  • 4Babst M. A protein's final ESCRT. Traffic, 2005, 6: 2-9.
  • 5Ostrowski M, Carmo NB, Krumeich S, et al. Rab27a and Rab27b control different steps of the exosome secretion pathway. Nat Cell Biol, 2010, 123: 235-243.
  • 6Beach A, Zhang HG, Ratajczak MZ, et al. Exosomes: an overview of biogenesis, composition and role in ovarian cancer. J Ovarian Res, 2014, 7:1-11.
  • 7Peinado H, Aleckovic M, Lavotshkin S, et al. Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET. Nat Med, 2012, 18: 883-891.
  • 8Kim HS, Choi DY, Yun SJ, et al. Proteomic analysis of microvesicles derived from human mesenchymal stem cells. J proteome Res, 2011, 11: 839-849.
  • 9Thery C, Amigorena S, Raposo G, et al. Isolation and characterization of exosomes from celculture supernatants and biological fluids. Curt Protoe Cell Biol, 2006, Chapter 3: Unit 3.22.
  • 10Momen-Heravi F, Balaj L, Alian S, et al. Current methods for the isolation of extracellular vesicles. BiolChem, 2013, 394: 1253-1262.

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