代谢综合征对寻常型银屑病患者皮损严重程度和生活质量的影响

Effect of metabolic syndrome on the severity and quality of life in patients with psoriasis vulgaris

目的研究代谢综合征(MS)对寻常型银屑病患者皮损严重程度和生活质量的影响。方法全组患者127例,伴MS患者49例,不伴MS患者78例。记录患者性别、年龄、血压、血脂、空腹血糖、肝肾功能、血脂全项、BMI,计算两组患者银屑病皮损面积及严重度指数(PASI),利用DLQI量表对患者进行生活质量调查,比较两组患者的PASI和DLQI量表分值。结果研究发现两组患者银屑病严重程度的分布情况有明显差异,伴MS患者严重程度明显较重,伴MS患者PASI≥20分的例数较不伴MS组明显增多,而处于0分<PASI≤10分的例数明显少于不伴MS组。另外伴MS患者中生活质量受到重度影响和极重度影响的患者例数更多,而不伴MS患者生活质量无影响或轻度影响的患者例数更多。结论 MS会加重银屑病患者皮损严重程度,严重影响患者的生活质量。

Objective To study the effect of metabolic syndrome （MS） on the severity and quality of life in patients with psoriasis vulgaris. Methods 127 patients were selected in the study, 49 patients with MS and 78 patients without MS. Age, blood pressure, blood lipids, fasting blood glucose, liver and kidney function, blood lipids full and BMI of the patients were recorded. Calculated the psoriasis area and severity index （PASI） in all patients, the quality of life was evaluated by the dermatology life quality index （DLQI）. Compared PASI and DLQI between the two groups of patients. Results Psoriasis pa-tients with MS was more serious than the other patients. The number of patients with MS whose PASI was more than 20 in MS group was larger than those without MS, and patients with 0〈PASI≤10 was less than those without MS. In addition, the number of patients with severe and very severe effect on the quality of life in MS group was more than the group without MS. And pa-tients without effect or mild effect on the quality of life in MS group was less than the group without MS. Conclusion MS can aggravate the severity of skin lesions in patients with psoriasis , seriously affect the quality of life of patients.