紫金化毒栓抗炎、镇痛、止痒作用研究

Study on Antiinflammatory,Analgesic and Antipruritic Effects of Zijin Detoxicating Suppository

目的评价紫金化毒栓抗炎、镇痛、止痒的药效作用。方法采用二甲苯致小鼠耳肿胀、皮肤毛细血管通透性试验,大鼠棉球肉芽肿试验观察其抗炎作用;采用热板和冰醋酸致小鼠扭体试验观察其镇痛作用;采用磷酸组织胺致豚鼠瘙痒和右旋糖酐致小鼠瘙痒模型观察其止痒作用。结果紫金化毒栓对二甲苯导致的小鼠耳肿胀和腹部皮肤毛细血管通透性升高具有明显的抑制作用,同时能明显降低棉球肉芽肿重量;紫金化毒栓具有升高小鼠痛阈值、降低扭体次数的作用,同时可以升高致痒阈、减少搔痒次数。结论紫金化毒栓具有抗炎、镇痛、止痒的药理作用。

Objective To evaluate the antiinflammatory, analgesic and antipruritic effects of Zijin detoxicating suppository （ZJDS）. Methods To observe the antiinflammatory effect of ZJDS, the tests of ear swelling and skin capillary permeability induced by xylene and the test of rat granuloma were carried out. To investigate analgesic effect, hot plate and acetic acid induced writhing tests in mice were performed. To discover antipruritic effect of ZJDS, pruritus of guinea pig was induced by phosphoric acid histamine and pruritus of mice was induced by dextran. Results ZJDS showed obvious inhibition effect on mice ear swelling and abdominal skin capillary permeability increase, and significantly reduced the weight of cotton pellet granuloma. ZJDS can increase the pain and itch threshold of mice, and reduce the writhing times and the number of itching. Conclusion ZJDS possessed the pharmacological effects of antiinflammation, analgesia and antipruritus.