活犀角与犀角促凝血作用的研究

Study on Procoagulant Activity of Living Rhino Horn and Rhino Horn

目的比较活犀角与犀角的促凝血作用有无明显差异,判断活犀角是否可以作为犀角的代用品。方法静脉注射凝血酶和氨基己酸,制造小鼠弥漫性血管内凝血(DIC)模型,研究对血小板、凝血酶时间(TT)、凝血酶原时间(PT)和活化部分凝血活酶时间(APTT)的作用。结果活犀角、犀角200 mg·kg-1明显增加DIC小鼠的血小板数量,明显缩短DIC模型小鼠的TT、PT和APTT。相同剂量活犀角、犀角的血小板数量和、TT、PT和APTT时间无明显差异。结论活犀角与犀角的促凝血作用无显著差异,在促凝血作用方面活犀角可以作为犀角的代用品进行使用。

Objective To observe the difference in procoagulant activity between living rhino horn and rhino horn by the comparative research method. Methods The procoagulant activity of the living rhino horn and traditional rhino horn was evaluated in DIC model mice by intravenous thrombin and amino caproic acid. Results The living rhino horn of 100, 200 mg·kg-1 significantly increased the number of platelets and shorten TT, PT and APTT of DIC model mice. There was no difference in procoagulant activity of traditional rhino horn and the living rhino horn at the same dose. Conclusion The procoagulant activity of living rhino horn is equal to that of the traditional rhino horn,and the living rhino horn can be used as a substitute of rhino horn.