宫颈癌术后不同放疗方式对疗效及周围组织影响的对比研究

Postoperative Radiation Therapy of Cervical Cancer and the Comparative Study of the Different Impact on the Surrounding Tissues

目的:探讨三维适形放疗(3DCRT)、强调适形放疗(IMRT)及常规放疗(CRT)三种不同放疗方式对宫颈癌术后患者的治疗疗效以及对病灶周围组织的影响。方法:选择2010年6月至2012年1月在我院诊断为宫颈癌Ⅰa、Ⅰb、Ⅱa、Ⅱb期,并在宫颈癌术后需行放射治疗的156名患者,根据不同的放疗方式分为3DCRT(1组)、IMRT(2组)和CRT(3组)三组,通过回顾分析三组患者的放疗方式,对比分析术后放疗患者的3年生存率及复发率,以及三种放疗方法对病灶周围组织的影响。结果:三种放疗方式3年内生存率无明显差异,复发率的排序为:3组>1组>2组,而三种方法对周围组织的影响程度表示为:3组>1组>2组,且差异显著,具有统计学意义(P<0.05)。结论:三维适形放疗(3DCRT)与强调适形放疗(IMRT)对宫颈癌术后的治疗效果均优于常规放疗(CRT),而且3DCRT与IMRT对靶区周围组织及器官的损伤明显低于CRT。

Objective:To investigate the three different ways about three-dimensional conformal radiotherapy(3DCRT),intensity modulated radiotherapy(IMRT)and conventional radiotherapy(CRT)on postoperative radiation therapy in patients with cervical cancer and the impact on the surrounding tissue lesions.Methods:Choose 156 patients who diagnosed with cervical cancerⅠ a,Ⅰb,Ⅱa,Ⅱb period in our hospital from June 2010 to January 2012,and those cervical cancer postoperative need radiotherapy.We divided those patients into three groups depending on the radiation way into 3DCRT(group 1),IMRT(group 2)and CRT(group 3).By retrospective analysis of the three groups of patients with radiotherapy and comparative analysis of postoperative radiotherapy in patients with relief of symptoms,the patient's survival rate and recurrence rate in 3years,as well as the lesion on surrounding tissue of the three radiotherapy methods.Results:The sorting of the three radiotherapy methods for treatment:Group2> Group1> group3,and the degree of influence on the surrounding tissue of the three methods is represented as:group3>group1>group2,and the difference was significant,statistically significance(P<0.05).Conclusions:The treatment effects of the three-dimension conformal radiotherapy(3DCRT)and intensity modulated radiotherapy(IMRT)for cervical cancer postoperative were superior to conventional radiotherapy(CRT),and intensity modulated radiotherapy(IMRT)is better than the three-dimension conformal radiotherapy(3DCRT).