溃疡性结肠炎患者的肠道菌群状况和双歧杆菌的疗效分析

Status of intestinal flora in patients with ulcerative colitis and analysis on curative effect of bifidobacteria

目的探讨溃疡性结肠炎(UC)患者的肠道菌群状况以及双歧杆菌的治疗效果。方法比较健康人群、活动期UC(AUC)以及缓解期UC(RUC)患者体内菌群状况,每组100例。将AUC组随机分为A和B组,每组50例;RUC组随机分为C和D组;A、C组给予常规药物治疗,B、D组给予活性双歧杆菌治疗,比较4周后的治疗效果。结果 AUC组患者与RUC组患者的双歧杆菌、乳酸杆菌、球状梭菌、拟杆菌的菌落数均显著低于对照组,AUC组患者与RUC组患者的大肠埃希菌、肠球菌均高于对照组,差异有统计学意义(P<0.05);AUC组患者的双歧杆菌、乳酸杆菌的菌落数显著低于RUC组患者,AUC组患者的大肠埃希菌菌落数明显高于RUC组患者,差异有统计学意义(P<0.05);治疗后,A组患者的双歧杆菌、乳酸杆菌的菌落数显著低于B组患者,A组患者的大肠埃希菌的菌落数显著高于B组患者,差异有统计学意义(P<0.05);治疗后,C组患者的双歧杆菌、乳酸杆菌菌落数显著低于D组患者,C组患者大肠埃希菌的菌落数显著高于D组患者,差异有统计学意义(P<0.05);B组患者的临床疗效以及组织学疗效均显著优于A组患者,差异有统计学意义(P<0.05);D组患者的临床疗效显著优于C组患者,差异有统计学意义(P<0.05)。结论 UC患者较健康人群有很大变化,有益菌明显减少,服用活性双歧杆菌可以有效地改善患者菌群的平衡,改善治疗效果。因此,结肠炎患者肠道内菌群平衡与治疗效果具有密切的联系。

Objective To investigate the status of intestinal flora in the patients with ulcerative colitis（UC） and the curative effect of bifidobacteria .Methods The intestinal flora status was compared among the normal population ,patients with active ulcerative colitis （AUC） and remission of ulcerative colitis （RUC ） ,100 cases in each group .The AUC group was randomly divided into the group A and B ,the RUC group were randomly divided into the group C and D ,50 cases in each group .The group A and C were given the routine medication therapy ,while the group B and D given the living bifidobacterial treatment .The curative effects after 4week treatment were compared among the groups .Results The bifidobacterium ,lactobacillus ,clostridium globular and bacteroides colony counts in the AUC group and the RUC group were significantly lower than those in the control group ,the E .coli and enterococcus colony counts in the AUC group and the RUC group were higher than those in the control group ,the differences were statistically significant（P〈 0 .05） ;the bifidobacterium and lactobacillus colony counts in the AUC group were significantly lower than those in the RUC group ,the E .coli colony count in the AUC group was significantly higher than that in the RUC group ,the differences were statistically significant（P 〈 0 .05） ;after treatment ,the bifidobacterium and lactobacillus colony counts in group A was significantly lower than that in the group B ,the E .coli colony count in the group A was significantly higher than that in the group B ,the difference was statistically significant（P〈 0 .05） ;after treatment ,the bifidobacterium and lactobacillus colony counts in the group C were significantly lower than those in the group D ,the E .coli colony count in the group C was significantly higher than that in the group D ,the difference was statistically significant（P〈 0 .05） ;the clinical curative effect and histological effect in the group B were significantly better than those in the group A ,the difference was statistically significant （ P 〈 0 .05） ;the clinical curative effect in the group D was significantly better than that in the group C ,the difference was statistically significant（P〈0 .05） .Conclusion The patients with UC have great changes compared with the healthy crowd ,the beneficial bacteria are decreased significantly ,taking living bifidobacterium can effectively improve the bacterial flora balance in the patients ,improves the treatment effect ,therefore ,the intestinal flora balance is closely related with the therapeutic effect in the UC patients .