切割与多聚腺苷酸化特异因子与肿瘤相关研究进展

Progress in the relation between cleavage and polyadenylation specific factor and tumor

在人类实体肿瘤中,首选治疗方法是手术切除,但多数临床确诊的肿瘤患者已处于中晚期,失去了手术机会.切割与多聚腺苷酸化特异因子是参与mRNA 3＇端的切割和多聚腺嘌呤poly （A）尾的添加,在mRNA成熟和细胞信号转导过程中扮演着重要的角色.在某些条件下,切割与多聚腺苷酸化特异因子表达的异常能导致癌基因的激活,进而引起肿瘤的发生.本文就切割与多聚腺苷酸化特异因子与肿瘤相关研究进行综述.

For human solid tumors,the preferred treatment is surgery.However most patients with clinical diagnosis of tumor is already in advanced,and lost the chance of operation.Cleavage and polyadenylation specific factor is involved in mRNA 3＆#39; end cleavage and polyadenine （A） tail,and plays an important role in mRNA maturation and intracellular singal transduction.Under certain conditions,cleavage and polyademletion specific factor can lead to abnormal activation of cancer genes,and then cause tumors.Progress in the relation between cleavage and polyademletion specific factor and tumor was reviewed in the paper.