清脂颗粒干预酒精性脂肪肝形成的实验研究及对大鼠血清TNF-α、Leptin水平的影响

Experimental Study of Qingzhi Granule on the Formation of Alcoholic Fatty Liver and Its Effect on the Level of Rat Serum TNF-ɑ and Leptin

目的:探讨中药清脂颗粒对酒精性脂肪肝大鼠的疗效和作用机制。方法:采用复合造模方法诱导大鼠酒精性脂肪肝模型,给予中药清脂颗粒干预,观察肝组织病理形态和血脂、肝功能、细胞因子瘦素Leptin和肿瘤坏死因子TNF-α等的变化。结果:试验组大鼠血清TC、TG、LDL-C、HDL-C及肝功ALT、AST、GGT明显改善,并且具降低血清瘦素Leptin及肿瘤坏死因子TNF-α含量的作用。结论:中药清脂颗粒可通过改善血脂、肝功指标、降低血清TNF-α,Leptin水平,达到防治酒精性脂肪肝的目的。

Objective：To investigate the effect and mechanism of traditional Chinese medicine Qingzhi granule on rats with alco-holic fatty liver.Methods：The composite molding method was used to induce alcoholic fatty liver rat model,and they were treated with traditional Chinese medicine Qingzhi granule intervention.The changes of liver histopathology and blood lipid,liver function, cytokine leptin Leptin and tumor necrosis factor alpha TNF-etc were observed.Conclusion：Traditional Chinese medicine Qingzhi granules can achieve the goal of the prevention and treatment of alcoholic fatty liver by improving blood lipid,liver function,and reducing serum TNF-α,Leptin level.