巨噬细胞移动抑制因子在乳腺浸润性导管癌组织中的表达及意义

Expression and significance of macrophage migration inhibitory factors(MIF) in the breast infiltrating duct cancer

目的探讨巨噬细胞移动抑制因子(MIF)在乳腺浸润性导管癌组织中的表达及意义。方法收集我院110例乳腺浸润性导管癌患者新鲜标本,采用免疫组织化学法检测MIF在110例乳腺浸润性导管癌组织和癌旁正常组织中的表达水平,并分析MIF表达水平与腋窝淋巴结有无转移、雌、孕激素受体以及Her-2表达情况之间的关系。结果 MIF在乳腺癌组织中的阳性率为74.55%,明显高于癌旁正常组织46.36%,差异有统计学意义(P<0.01);MIF的表达与腋窝淋巴结转移有关(P<0.05),与雌、孕激素受体及Her-2表达情况无关(P>0.05)。结论 MIF作为一种重要的多功能细胞因子,可能在乳腺癌的发生与侵袭过程中发挥重要作用。

Objective To investigate the expression and significance of macrophage migration inhibitory factors （MIF） in the breast infiltrating duct cancer.MethodsColected the breast cancer patients’ samples in our hospital. Immunohistochemistry was used to detect the expressions of MIF in 110 breast infiltrating duct cancer and the adjacent normal breast tissues. The relationship between their expression and the clinical pathology was analyzed.Results The positive expression rate of MIF in the tissue of breast cancer was 74.55%, which was obviously higher than that （46.36%） in the corresponding adjacent normal breast tissues （P〈0.01）; The positive expression of MIF had significant difference in the lymph node metastasis （P〈0.05）, and it had no significant difference in the ER, PR or Her-2 （P〉0.05）. Conclusion It suggests that MIF may play an important role in the tumorigenesis and invasion of breast carcinoma through some mechanism.