小细胞肺癌维持治疗的研究进展

Research Progression of Maintenance Therapy in Small Cell Lung Cancer

肺癌是世界上最常见的恶性肿瘤之一,其中小细胞肺癌发生率约15%。小细胞肺癌对一线化疗高度敏感,但多数患者在一线治疗缓解后很快出现复发进展,因此,自20世纪80年代起已开展不少小细胞肺癌维持治疗的相关临床研究,涉及到化疗药物、生物制剂及分子靶向药物。但其结果仍存在争论,现对该方面内容综述如下。

Lung cancer is one of the common malignant tumors in the world, the incidence of small cell lung cancer is about 15% among them. Small ceU lung cancer is highly sensitive to first-line chemotherapy3 but most of the patients relapse after the first-line therapy quickly. Despitemany clinical researchof chemotherapy, biological agents and molecular targeting agents since the 1980s, there still remains a substantial lack of consensus regarding the appropriate therapeutic management on maintenance therapy of small cell lung cancer. The review focuses on maintenance therapy of small cell lung cancer.