铂类抗肿瘤药物相关肾损伤作用机制的研究进展

Mechanism of Platinum Derivatives Induced Kidney Injury

铂类药物是目前应用最广泛的抗肿瘤药物之一,广泛应用于卵巢癌、睾丸肿瘤、头颈部肿瘤、肺癌和结直肠癌等恶性实体瘤中,然而,其严重的不良反应以及耐药问题限制了其临床应用。同时该类药物可引起较严重的不良反应,从而限制了铂类药物的临床应用范围。其中,限制顺铂使用的最主要因素是肾脏毒性。本文就不同铂类药物引起肾损伤的作用机制进行综述。

Platinum derivatives are the most widely used chemotherapeutic agents to treat solid tumors including ovarian, head and neck, and testicular germ cell tumors, lung cancer, and colorectal cancer. Two major problems exist, however, in the clinic use of platinum derivatives. One is the development of tumor resistance to the drug during therapy, leading to treatment failure, The other is the drug＇s toxicity such as the cisplatin＇s nephrotoxicity, which limits the dose that can be admin- istered. This paper describes the mechanism of platinum derivatives induced kidney injury.