血清25-(OH)D_3水平与糖尿病肾病关系的临床研究

Association of serum 25-hydroxy vitamin D_3 level with diabetic nephropathy

目的研究血清25-(OH)D3与糖尿病肾病(DN)的关系。方法根据糖尿病肾脏病变诊断标准,将301例糖尿病患者分为DN组和非DN组,分别记录性别、年龄、糖尿病病程,测量身高、体质量、腰围、臀围,计算体质量指数(BMI)和腰臀比(WHR),并采用酶联免疫吸附法(ELISA)测定血清25-(OH)D3水平,比较两组均值,并分析25-(OH)D3与BMI、腰围、臀围、腰臀比及糖尿病病程的相关性。结果 DN组与非DN组患者性别、年龄、身高、体质量、体质指数、腰围、臀围、WHR均无统计学意义(P>0.05);而DN组糖尿病病程(15.39±7.27)年,明显高于非DN组病程(12.01±6.45)年,血清25-(OH)D3水平(35.27±10.29)nmol·ml-1明显低于非DN组患者血清25-(OH)D3水平(39.79±13.16)nmol·ml-1,有统计学意义(P<0.05)。血清25-(OH)D3与BMI、腰围、臀围、WHR均无相关(r分别为0.041,0.111,0.071,0.001,P均>0.05);与糖尿病病程呈负相关(r为-0.174,P<0.05)。结论 DN患者较非DN患者糖尿病病程更长,血清25-(OH)D3水平更低;且糖尿病患者病程越长,血清25-(OH)D3水平越低。

Objective To study the relationship between serum 25-hydroxy vitamin D3 [ 25-（OH） D3 ] level and diabetic nephropathy （DN）. Methods Three hundred and one patients with diabetic mellitus were enrolled in the study, including 97 cases with diabetic nephropathy （DN group） and 204 cases without diabetic nephropathy （ non-DN group）. Sex, age, diabetes duration, height, weight, waist circumference （ WC）, hip circumference （HC） were recorded, and body mass index （ BMI）, waist/hip ratio （WHR） were calculated. Serum 25-（ OH ）D3 levels were measured by enzyme-linked immunosorbent assay （ELISA）. The correlation of 25- （OH） D3 level with BMI, WC, HC, WHR, diabetes duration was analyzed. Results There were not statistical significances in sex, age, height, weight, WC, HC , BMI and WHR between DN and non-DN groups （ P 〉 0.05 ）. However, the diabetes duration in DN group was longer than that in non-DN group and serum 25-（OH） D3 level in DN group was lower than that in non-DN group. Serum 25-（OH） D3 level was negatively correlated with the diabetes duration（ r = -0. 174 ,P 〈 0.05 ）, and not correlated with BMI, WC, HC and WHR （r=0.041,0. 111,0.071 and 0.001,P〉0.05）. Conclusion DN patients have longer diabetes duration and lower serum 25- （OH） D3 level than non-DN patients.