基于VBM的轻度认识障碍患者脑灰质体积改变的纵向研究

Grey matter volume in mild cognitive impairment patients:a longitudinal study based on VBM

目的探讨轻度认知障碍患者随访1年后脑灰质体积改变。方法利用体素的形态测量学(voxel-based morphometry,VBM)方法,对来自ADNI(Alzheimer disease Neuroimaging Initiative)数据库的70例M CI患者及44例正常对照者基线及随访1年的脑灰质体积改变进行对比研究。对两组人2次3D磁共振T1结构像进行预处理,得到平滑后的全脑灰质数据,运用配对样本t检验,分别比较正常对照组前后1年脑灰质体积差异及MCI组前后1年脑灰质体积差异。结果正常对照者在1年前后脑灰质体积无明显改变;MCI组患者皮质脑灰质体积在随访1年后相关脑区有明显的萎缩(P<0.05),这些区域主要集中在:记忆相关的颞叶区域,包括左颞下回、左颞中回、右颞上回、左侧海马、右侧海马;语言功能及躯体感觉相关区域等,包括左侧岛叶、右楔叶、右中央后回。结论 MCI患者在1年时间内脑灰质在与记忆相关的颞叶区域及与语言功能和躯体感觉相关区域有发生萎缩,可为阿尔茨海默病的早期诊断提供影像学依据。

Objective To investigate the changes of grey matter volume in mild cognitive impairment （MCI） patients during 1-year follow up. Methods 3.0T MRI images of 70 MCI patients and 44 healthy subjects were download from Alzheimer disease Neuroimaging Initiative（ADNI） database. Based on the voxel-based morphometry （VBM） method, the images were preprocessed and the smoothed data of whole brain gray matter were obtained. Statistical analysis was performed for the differences between baseline and 1-year follow-up data of patients and controls. Results There was no grey matter atrophy found in baseline imagines and after 1-year follow up in controls. Compared to controls, the atrophy of grey matter detected during the follow up in MCI patients, was mainly located in the following regions： regions related to memory, including the left temporal gyms, the left middle temporal gyms, the rightsuperior temporal gyms, the left hippocampus and the right hippocampus; regions related to linguistic function or somatic sensation, including the left insula gyms, the right cuneus and right postcentral gyms. Conclusion The atrophy of gray matter in MCI patients is mainly located in certain regions and these findings may provide imaging basis for early diagnosis of Alzheimer disease.