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Alpha烯醇化酶与疾病的相关性 被引量：5

Alpha-enolase and its association with diseases
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摘要 alpha-烯醇化酶(α-enolase,ENO1)是原核及真核细胞内糖酵解过程中的限速酶,参与纤溶酶原的激活和纤溶酶活化过程,促进肌生成和肌肉再生,调控细胞增殖与凋亡等过程,其在细胞内外表达量的变化与疾病的发生发展过程密切相关,如阿尔兹海默病、类风湿关节炎、肿瘤、心血管疾病等。 Alpha-enolase （ot-enolase, ENO1 ） is a key glycolytic enzyme in cytoplasm of prokaryotic and eukaryotic cells. It involves in plasminogen and plasmin activation, promotes muscle formation and regeneration, regulates cell proliferation and apoptosis. The differential expression of ENO1 inside and/or outside of cells is related to several pathological conditions, such as cancer, Alzheimer＇s disease, rheumatoid arthritis and cardiovascular disease.
作者 樊莎莎 范列英
机构地区 同济大学附属东方医院检验科 湖北恩施州民族医院检验科
出处 《同济大学学报（医学版）》 CAS 2015年第4期128-132,共5页 Journal of Tongji University(Medical Science)
基金 国家自然科学基金面上项目(81373203) 国家自然科学基金青年项目(81302563)
关键词 alpha-烯醇化酶 肿瘤 类风湿关节炎 阿尔兹海默病 心血管疾病 alpha-enolase cancer rheumatoid arthritis Alzheimer＇s disease cardiovasculardisease
分类号 R593 [医药卫生—内科学]
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参考文献26

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同被引文献40

  • 1郭明阳,周厚永,张明友.类风湿因子阳性意义评价[J].西南军医,2004,6(4):49-50. 被引量：8
  • 2Caturegli P,De Remigis A, Rose NR, et al.Hashimoto thyroiditis: clinical and diagnostic criteria[J].Autoimmun Rev, 2014,13(4/5):391-397.
  • 3Park JS, Lee SJ, Kim TH.Gastric autoantigenic proteins in helico- bacter pyloriinfection[J].Yonsei Med J,2013,54(6):1342-1352.
  • 4Kinloch AJ,Alzabin S,Brintnell W.Immunization with porphyromo- nas gingivalis enolase induces autoimmunity to mammalian a-eno- lase and arthritis in DR4- IE - transgenic mice[J].Arthritis Rheum, 2011,63(12):3818-3823.
  • 5Diaz - Ramos A, Roig-Borrellas A, Garcia-Melero A.a-enolase, a multifunctional protein: its role on pathophysiological situations[J]. J Biomed Biotechnol,2012,2012(7):156795.
  • 6Pontillo A, Di Toro N,Edomi P.Anti-a-enolase antibodies in serum frompediatric patients affected by inflammatory diseases : diagnostic and pathogenetic insights[J].Int J Rheumatol,2011,2011:870214.
  • 7Terrier B,Degand N,Guilpain P.Alpha-enolase : a target of antibod- ies in infectious and autoimmune diseases[J].Autoimmun Rev, 2007,6(3):176-182.
  • 8Fujii A, Yoneda M,Ito T.Autoantibodies against the amino terminal of alpha-enolase are a useful diagnostic marker of Hashimoto's en- cephalopathy[J].J Neuroimmunol,2005,162(1/2):130-136.
  • 9Yoneda M, Fujii A, Ito A.High prevalence of serum autoantibodies against the amino terminal of alpha-enolase in s enceph- alopathy[J].J Neuroimmunol,2007,185(1/2):195-200.
  • 10Lee JY,Choi IA, Kim JH.Association between anti - Porphyromonas gingivalis or anti-a-enolase antibody and severity of periodontitis or rheumatoid arthritis (RA)disease activity in RA severity of peri- odontitis or rheumatoid arthritis (RA)disease activity in RA[J]. BMC Musculoskele Disord,2015,16(1):190-197.

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同济大学学报（医学版）
2015年 第4期

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