聚合物-药物结合物递药系统的研究进展

The Development of Drug Delivery System Based on Polymer-Drug Conjugates

聚合物-药物结合物作为新型的递药系统,在药学领域应用广泛。它能够有效地提高药物的水溶性,改善其体内外行为,增强治疗指数并保护药物分子免遭降解。文章主要讨论了聚合物载体、化学连接链和给药途径这3大设计因素对聚合物-药物结合物递药系统的影响,并以新兴的聚合物载体为分类标准对该领域的最新研究进展进行了概述,以期为后续研究提供参考。

Polymer-drug conjugates as a novel drug delivery system have been widely used in the field of pharmaceutics. It can effectively increase the aqueous solubility of parent drugs,improve their in vitro and in vivo behaviors,enhance the therapeutic efficiency and protect drug molecules against degradation. In this review,the important factors including polymer selection,chemical linker and administration routes that determine the rational design of polymer-drug conjugates were mainly discussed. Moreover,using novel polymer carriers as classification criterion,the recent achievements in the field of polymer-drug conjugates have been summarized in order to guide the further studies.