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泛素-蛋白酶体系统在神经退行性疾病中的研究 被引量：8

The Research of Ubiquitin-proteasome System in Neurodegenerative Diseases
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摘要 泛素-蛋白酶体系统(UPS)是真核细胞内蛋白质降解的主要信号通路,UPS在降解细胞内错误折叠受损的蛋白也起着重要作用。神经退行性疾病的共同特征是中枢神经系统的细胞内或细胞外异常聚集着突变或损伤的蛋白,如帕金森病(PD)、阿尔茨海默病(AD)、亨廷顿病(Huntington)等。而且UPS成分的突变也可导致神经退行性疾病[1]。因此,UPS的功能异常影响着神经退行性疾病的发生发展。 Ubiquitin-proteasome system（ UPS） is the main signal path of protein degradation in the eukaryotic cells. UPS plays an important role in the degradation of misfolded damaged cell proteins. Common feature of neurodegenerative diseases is the central nervous system cells or extracellular abnormal accumulation of mutations or damage of proteins,such as Parkinson’s disease（ PD）,Alzheimer’s disease（ AD）,Huntington’s disease（ Huntington）,etc. Mutations of UPS component may also lead to neurodegenerative diseases. Therefore,UPS dysfunction affects the development of neurodegenerative diseases.
作者 金雪佳
机构地区 温岭市第四人民医院
出处 《药物生物技术》 CAS 2015年第4期366-368,共3页 Pharmaceutical Biotechnology
关键词 泛素-蛋白酶体系统 神经退行性疾病 帕金森病 阿尔茨海默病 亨廷顿病 肌萎缩侧索硬化 Ubiquitin-proteasome system Neurodegenerative disease Parkinson’ s disease Alzheimer’ s disease Huntington’ s disease Amyotrophi
分类号 Q55 [生物学—生物化学]
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参考文献15

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同被引文献76

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药物生物技术
2015年 第4期

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