急性心力衰竭心肾阳虚证生物学标志物与预后相关性研究

Correlation between Biomarkers and Prognosis of Acute Heart Failure Patients with Heart-kidney Yang-deficiency Syndrome

目的:探讨急性心力衰竭心肾阳虚证患者生物学标志物与预后的相关性。方法:观察129例急性心力衰竭心肾阳虚证患者肌酐(Cr)、月光抑素C(CysC)、B型利钠肤(BNP)、肌钙蛋白I(eTnI)、肾小球滤过率(eGFR)水平,并随访2年,评价生物学标志物与预后的相关性。结果:急性心力衰竭心肾阳虚证患者2年内死亡者CysC水平显著高于未死亡者(P<0.05),而Cr、BNP、eTnI、eGFR水平无显著差异。结论:血CysC浓度可以作为评估急性心衰心肾阳虚证患者2年生存率的重要生物学标志物。

Objective： To investigate the correlation between biomarkers and prognosis of acute heart failure patients with heart-kidney yang-deficiency syndrome. Methods. A total of 129 acute heart failure patients with heart-kidney yang-deficiency syndrome received the blood testing for creatinine（Cr）, cystatin C（CysC）, B-type natriuretic peptide（BNP） and cardiac troponin I（cTnl）. Besides the estimated glomerular filtration rate（eGFR） was calculated. The correlation between these biomarkers and 2-year prognosis was analyzed. Results. The level of CysC in patients who died within two years was much higher than those who were alive（P 〈 0.05）. However, there were no statistic difference between two groups in the level of Cr, BNP and cTnl. Conclusion： The level of CysC is positively correlated with the 2-year prognosis of acute heart failure patients with heart-kidney yang-deficiency syndrome.